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  Evidence of direct cell-cell fusion in Borrelia by cryogenic electron tomography

Kudryashev, M., Cyrklaff, M., Alex, B., Lemgruber, L., Baumeister, W., Wallich, R., et al. (2011). Evidence of direct cell-cell fusion in Borrelia by cryogenic electron tomography. Cellular Microbiology, 13(5), 731-741. doi:10.1111/j.1462-5822.2011.01571.x.

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 Creators:
Kudryashev, Misha1, Author              
Cyrklaff, Marek1, 2, Author              
Alex, Björn1, 3, Author
Lemgruber, Leandro 1, Author
Baumeister, Wolfgang2, Author              
Wallich, Reinhard 3, Author
Frischknecht, Friedrich 1, Author
Affiliations:
1Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
3Institute for Immunology, University of Heidelberg Medical School, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Some Borrelia species are the causative agents of tick-borne Lyme disease responsible for different disabilities depending on species and hosts. Borrelia are highly motile bacterial cells, and light microscopy shows that these spirochetes can associate with each other during movement. Using cryo-electron tomography, we observed closely associated Borrelia cells. Some of these showed a single outer membrane surrounding two longitudinally arranged cytoplasmic cylinders. We also observed fusion of two cytoplasmic cylinders and differences in the surface layer density of fused spirochetes. These processes could play a role in the interaction of Borrelia species with the host's immune system.

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Language(s): eng - English
 Dates: 2010-12-142010-09-152010-12-222011-04-182011-05-01
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/j.1462-5822.2011.01571.x
PMID: 21276171
 Degree: -

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Title: Cellular Microbiology
Source Genre: Journal
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Publ. Info: Malden, MA : Blackwell Science
Pages: - Volume / Issue: 13 (5) Sequence Number: - Start / End Page: 731 - 741 Identifier: ISSN: 1462-5814
CoNE: https://pure.mpg.de/cone/journals/resource/959328105032