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  The carbon isotope ratios of nonessential amino acids identify sugar-sweetened beverage (SSB) consumers in a 12-wk inpatient feeding study of 32 men with varying SSB and meat exposures

Johnson, J. J., Shaw, P. A., Oh, E. J., Wooller, M. J., Merriman, S., Yun, H. Y., et al. (2021). The carbon isotope ratios of nonessential amino acids identify sugar-sweetened beverage (SSB) consumers in a 12-wk inpatient feeding study of 32 men with varying SSB and meat exposures. The American Journal of Clinical Nutrition, 113(5): nqaa374, pp. 1256-1264. doi:10.1093/ajcn/nqaa374.

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 Creators:
Johnson, Jessica J, Author
Shaw, Pamela A, Author
Oh, Eric J, Author
Wooller, Matthew J, Author
Merriman, Sean, Author
Yun, Hee Young, Author
Larsen, Thomas1, Author           
Krakoff, Jonathan, Author
Votruba, Susanne B, Author
O'Brien, Diane M, Author
Affiliations:
1Archaeology, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074312              

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Free keywords: amino acid carbon isotope ratios, alanine, controlled-feeding study, NIDDK, sugar-sweetened beverages
 Abstract: BACKGROUND: The carbon isotope ratios (CIRs) of individual amino acids (AAs) may provide more sensitive and specific biomarkers of sugar-sweetened beverages (SSBs) than total tissue CIR. Because CIRs turn over slowly, long-term controlled-feeding studies are needed in their evaluation. - OBJECTIVE: We assessed the responses of plasma and RBC CIRAA's to SSB and meat intake in a 12-wk inpatient feeding study. - METHODS: Thirty-two men (aged 46.2 ± 10.5 y) completed the feeding study at the National Institute of Diabetes and Digestive and Kidney Diseases in Phoenix, Arizona. The effects of SSB, meat, and fish intake on plasma and RBC CIRAA's were evaluated in a balanced factorial design with each dietary variable either present or absent in a common weight-maintaining, macronutrient-balanced diet. Fasting blood samples were collected biweekly from baseline. Dietary effects on the postfeeding CIR of 5 nonessential AAs (CIRNEAA's) and 4 essential AAs (CIREAA's) were analyzed using multivariable regression. - RESULTS: In plasma, 4 of 5 CIRNEAA's increased with SSB intake. Of these, the CIRAla was the most sensitive (β = 2.81, SE = 0.38) to SSB intake and was not affected by meat or fish intake. In RBCs, all 5 CIRNEAA's increased with SSBs but had smaller effect sizes than in plasma. All plasma CIREAA's increased with meat intake (but not SSB or fish intake), and the CIRLeu was the most sensitive (β = 1.26, SE = 0.23). CIRs of leucine and valine also increased with meat intake in RBCs. Estimates of turnover suggest that CIRAA's in plasma, but not RBCs, were in equilibrium with the diets by the end of the study. - CONCLUSIONS: The results of this study in men support CIRNEAA's as potential biomarkers of SSB intake and suggest CIREAA's as potential biomarkers of meat intake in US diets. This trial was registered at clinicaltrials.gov/ct2/show/NCT01237093 as NCT01237093.

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Language(s): eng - English
 Dates: 2021-03-012021-05
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: Introduction
Methods
- Subjects and study design
- Outcome measures: CIRAA's in plasma and RBCs
- Statistical analyses

Results
- Study participants
- Effects of SSB and meat intake on postintervention CIRAA
- CIRAA turnover
Discussion
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/ajcn/nqaa374
Other: shh2867
 Degree: -

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Title: The American Journal of Clinical Nutrition
Source Genre: Journal
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Publ. Info: Bethesda, MD, USA : American Society for Nutrition
Pages: - Volume / Issue: 113 (5) Sequence Number: nqaa374 Start / End Page: 1256 - 1264 Identifier: ISSN: 0002-9165
CoNE: https://pure.mpg.de/cone/journals/resource/0002-9165