English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Disruption of oligodendrogenesis impairs memory consolidation in adult mice

Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R., Geraghty, A. C., et al. (2020). Disruption of oligodendrogenesis impairs memory consolidation in adult mice. Neuron, 105, 150-164.e6. doi:10.1016/j.neuron.2019.10.013.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0008-20AC-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-4F46-1
Genre: Journal Article

Files

show Files
hide Files
:
10.1016_j.neuron.2019.10.013.pdf (Publisher version), 6MB
 
File Permalink:
-
Name:
10.1016_j.neuron.2019.10.013.pdf
Description:
-
OA-Status:
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://doi.org/10.1016/j.neuron.2019.10.013 (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Steadman, Patrick E.1, Author
Xia, Frances1, Author
Ahmed, Moriam1, Author
Mocle, Andrew J.1, Author
Penning, Amber R.A.1, Author
Geraghty, Anna C.1, Author
Steenland, Hendrik W.2, Author
Monje, Michelle1, Author
Josselyn, Sheena A.1, Author
Frankland, Paul W.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society, Weinberg 2, 06120 Halle, DE, ou_3287471              

Content

show
hide
Free keywords: -
 Abstract: The generation of myelin-forming oligodendrocytes persists throughout life and is regulated by neural activity. Here we tested whether experience-driven changes in oligodendrogenesis are important for memory consolidation. We found that water maze learning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tracts. Preventing these learning-induced increases in oligodendrogenesis without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as contextual fear, memories. These results suggest that de novo myelination tunes activated circuits, promoting coordinated activity that is important for memory consolidation. Consistent with this, contextual fear learning increased the coupling of hippocampal sharp wave ripples and cortical spindles, and these learning-induced increases in ripple-spindle coupling were blocked when oligodendrogenesis was suppressed. Our results identify a non-neuronal form of plasticity that remodels hippocampal-cortical networks following learning and is required for memory consolidation.

Details

show
hide
Language(s):
 Dates: 2020-01-08
 Publication Status: Issued
 Pages: 22
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuron.2019.10.013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 105 Sequence Number: - Start / End Page: 150 - 164.e6 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565