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  Disruption of oligodendrogenesis impairs memory consolidation in adult mice

Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R., Geraghty, A. C., et al. (2020). Disruption of oligodendrogenesis impairs memory consolidation in adult mice. Neuron, 105, 150-164.e6. doi:10.1016/j.neuron.2019.10.013.

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10.1016_j.neuron.2019.10.013.pdf (Publisher version), 6MB
 
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https://doi.org/10.1016/j.neuron.2019.10.013 (Publisher version)
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Steadman, Patrick E.1, Author
Xia, Frances1, Author
Ahmed, Moriam1, Author
Mocle, Andrew J.1, Author
Penning, Amber R.A.1, Author
Geraghty, Anna C.1, Author
Steenland, Hendrik W.2, Author
Monje, Michelle1, Author
Josselyn, Sheena A.1, Author
Frankland, Paul W.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society, Weinberg 2, 06120 Halle, DE, ou_3287471              

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 Abstract: The generation of myelin-forming oligodendrocytes persists throughout life and is regulated by neural activity. Here we tested whether experience-driven changes in oligodendrogenesis are important for memory consolidation. We found that water maze learning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tracts. Preventing these learning-induced increases in oligodendrogenesis without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as contextual fear, memories. These results suggest that de novo myelination tunes activated circuits, promoting coordinated activity that is important for memory consolidation. Consistent with this, contextual fear learning increased the coupling of hippocampal sharp wave ripples and cortical spindles, and these learning-induced increases in ripple-spindle coupling were blocked when oligodendrogenesis was suppressed. Our results identify a non-neuronal form of plasticity that remodels hippocampal-cortical networks following learning and is required for memory consolidation.

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 Dates: 2020-01-08
 Publication Status: Published in print
 Pages: 22
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 Identifiers: DOI: 10.1016/j.neuron.2019.10.013
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 105 Sequence Number: - Start / End Page: 150 - 164.e6 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565