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  The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla

Voelker, M. N., Kraff, O., Goerke, S., Laun, F. B., Hanspach, J., Pine, K., et al. (2021). The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla. NeuroImage, 232: 117910. doi:10.1016/j.neuroimage.2021.

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Voelker, Maximilian N.1, Author
Kraff, Oliver2, Author
Goerke, Steffen3, Author
Laun, Frederik B.4, Author
Hanspach, Jannis4, Author
Pine, Kerrin5, Author              
Ehses, Philipp6, Author
Zaiss, Moritz4, 7, Author              
Liebert, Andrzej4, Author
Straub, Sina4, Author
Eckstein, Korbinian8, Author
Robinson, Simon8, Author
Nagel, Armin N.4, Author
Stefanescu, Maria R.9, Author
Wollrab, Astrid10, Author
Klix, Sabrina11, Author
Felder, Jörg12, Author
Hock, Michael9, Author
Bosch, Dario7, Author              
Weiskopf, Nikolaus5, 13, Author              
Speck, Oliver10, 14, AuthorLadd, Mark E.1, 3, 15, AuthorQuick, Harald H.1, 2, Author more..
1Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Germany, ou_persistent22              
2High Field and Hybrid MR Imaging, University of Duisburg-Essen, Germany, ou_persistent22              
3Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ou_persistent22              
4Institute of Radiology, University Clinic Erlangen, Germany, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
6German Center for Neurodegenerative Diseases, Bonn, Germany, ou_persistent22              
7Department of High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
8Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria, ou_persistent22              
9Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Germany, ou_persistent22              
10Otto von Guericke University Magdeburg, Germany, ou_persistent22              
11Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Germany, ou_persistent22              
12Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
13Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
14Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              
15Department of Physics and Astronomy, University of Heidelberg, Germany, ou_persistent22              


Free keywords: Magnetic resonance imaging; multicenter; quantitative imaging; reproducibility; ultrahigh field.
 Abstract: Object: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. Material and methods: Two subjects - termed the "traveling heads" - were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined. Results: Quantitative measurements with MP2RAGE showed very high reproducibility across sites and subjects, and errors were in concordance with previous results and other field strengths. QSM had high inter-site reproducibility for relevant subcortical volumes. CEST imaging revealed systematic differences between the sites, but reproducibility was comparable to results in the literature. Relaxometry had also very high agreement between sites, but due to the high sensitivity, differences caused by different applications of the B1 calibration of the two RF coil types used were observed. Conclusion: Our results show that quantitative brain imaging can be performed with high reproducibility at 7 T and with similar reliability as found at 3 T for multicenter studies of the supratentorial brain.


Language(s): eng - English
 Dates: 2021-01-252020-10-222021-02-202021-02-272021-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021
PMID: 33647497
Other: epub 2021
 Degree: -



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Project name : -
Grant ID : LA 1325/7-1, QU 154/5-1, SP 632/9-1, LA 2804/12-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : 01EO1504
Funding program : -
Funding organization : German Ministry of Education and Research

Source 1

Title: NeuroImage
Source Genre: Journal
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 232 Sequence Number: 117910 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166