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  Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort

Trofimova, O., Loued-Khenissi, L., DiDomenicantonio, G., Lutti, A., Kliegel, M., Stringhini, S., et al. (2021). Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2021.02.002.

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 Creators:
Trofimova, Olga1, Author
Loued-Khenissi, Leyla1, Author
DiDomenicantonio, Giulia1, Author
Lutti, Antoine1, Author
Kliegel, Matthias2, Author
Stringhini, Silvia3, 4, Author
Marques-Vidal, Pedro5, Author
Vollenweider, Peter5, Author
Waeber, Gérard5, Author
Preisig, Martin6, Author
Kherif, Ferath1, Author
Draganski, Bogdan1, 7, Author              
Affiliations:
1Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Faculty of Psychology and Educational Sciences, University of Geneva, Switzerland, ou_persistent22              
3Center for Primary Care and Public Health, University of Lausanne, Switzerland, ou_persistent22              
4Institute of Social and Preventive Medicine (IUMSP), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
6Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Aging; Cardiovascular disease; Cognition; Major depressive disorder; Quantitative magnetic resonance imaging
 Abstract: Given the controversy about the impact of modifiable risk factors on mood and cognition in ageing, we sought to investigate the associations between cardio-vascular risk, mental health, cognitive performance and brain anatomy in mid- to old age. We analysed a set of risk factors together with multi-parameter magnetic resonance imaging (MRI) in the CoLaus|PsyCoLaus cohort (n>1200). Cardio-vascular risk was associated with differences in brain tissue properties – myelin, free tissue water, iron content – and regional brain volumes that we interpret in the context of micro-vascular hypoxic lesions and neurodegeneration. The interaction between clinical subtypes of major depressive disorder and cardio-vascular risk factors showed differential associations with brain structure depending on individuals’ lifetime trajectory. There was a negative correlation between melancholic depression, anxiety and MRI markers of myelin and iron content in the hippocampus and anterior cingulate. Verbal memory and verbal fluency performance were positively correlated with left amygdala volumes. The concomitant analysis of brain morphometry and tissue properties allowed for a neuro-biological interpretation of the link between modifiable risk factors and brain health.

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Language(s): eng - English
 Dates: 2021-01-312020-09-182021-02-042021-02-16
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
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Project name : -
Grant ID : 32003B_135679, 32003B_159780, 324730_192755, CRSK-3_190185, 320030_184784, 32003B_173092, 3200B0_105993, 3200B0_118308, 33CSCO_122661, 33CS30_139468 and 33CS30_14840
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : Morphemic project
Grant ID : 871643
Funding program : -
Funding organization : European Union

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902