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  Translational control by ribosome pausing in bacteria: How a non-uniform pace of translation affects protein production and folding

Samatova, E. N., Daberger, J., Liutkute, M., & Rodnina, M. V. (2021). Translational control by ribosome pausing in bacteria: How a non-uniform pace of translation affects protein production and folding. Frontiers in Microbiology, 11: 619430. doi:10.3389/fmicb.2020.619430.

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Samatova, E. N.1, Autor                 
Daberger, J., Autor
Liutkute, M.1, Autor                 
Rodnina, M. V.2, Autor           
Affiliations:
1Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society, ou_578598              
2Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578598              

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Schlagwörter: translation, ribosome pausing, tRNA, prokaryotes, cotranslational folding, translation efficiency, nascent peptide
 Zusammenfassung: Protein homeostasis of bacterial cells is maintained by coordinated processes of protein production, folding, and degradation. Translational efficiency of a given mRNA depends on how often the ribosomes initiate synthesis of a new polypeptide and how quickly they read the coding sequence to produce a full-length protein. The pace of ribosomes along the mRNA is not uniform: periods of rapid synthesis are separated by pauses. Here, we summarize recent evidence on how ribosome pausing affects translational efficiency and protein folding. We discuss the factors that slow down translation elongation and affect the quality of the newly synthesized protein. Ribosome pausing emerges as important factor contributing to the regulatory programs that ensure the quality of the proteome and integrate the cellular and environmental cues into regulatory circuits of the cell.

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Sprache(n): eng - English
 Datum: 2021-01-11
 Publikationsstatus: Online veröffentlicht
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.3389/fmicb.2020.619430
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Titel: Frontiers in Microbiology
Genre der Quelle: Zeitschrift
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Seiten: 14 Band / Heft: 11 Artikelnummer: 619430 Start- / Endseite: - Identifikator: -