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  Mapping of multiple muscles with transcranial magnetic stimulation: Absolute and relative test–retest reliability

Nazarova, M., Novikov, P., Ivanina, E., Kozlova, K., Dobrynina, L., & Nikulin, V. V. (2021). Mapping of multiple muscles with transcranial magnetic stimulation: Absolute and relative test–retest reliability. Human Brain Mapping, 42(8), 2508-2528. doi:10.1002/hbm.25383.

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 Creators:
Nazarova, Maria1, 2, Author
Novikov, Pavel1, Author
Ivanina, Ekaterina1, Author
Kozlova, Ksenia1, Author
Dobrynina, Larisa3, Author
Nikulin, Vadim V.1, 4, Author              
Affiliations:
1Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
2Federal Medical-Biological Agency (FMBA), Moscow, Russia, ou_persistent22              
3Research Center of Neurology, Moscow, Russia, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Cortical mapping; Motor cortex; Muscle cortical representation; Overlap; Reliability; Transcranial magnetic stimulation
 Abstract: The spatial accuracy of transcranial magnetic stimulation (TMS) may be as small as a few millimeters. Despite such great potential, navigated TMS (nTMS) mapping is still underused for the assessment of motor plasticity, particularly in clinical settings. Here, we investigate the within‐limb somatotopy gradient as well as absolute and relative reliability of three hand muscle cortical representations (MCRs) using a comprehensive grid‐based sulcus‐informed nTMS motor mapping. We enrolled 22 young healthy male volunteers. Two nTMS mapping sessions were separated by 5–10 days. Motor evoked potentials were obtained from abductor pollicis brevis (APB), abductor digiti minimi, and extensor digitorum communis. In addition to individual MRI‐based analysis, we studied normalized MNI MCRs. For the reliability assessment, we calculated intraclass correlation and the smallest detectable change. Our results revealed a somatotopy gradient reflected by APB MCR having the most lateral location. Reliability analysis showed that the commonly used metrics of MCRs, such as areas, volumes, centers of gravity (COGs), and hotspots had a high relative and low absolute reliability for all three muscles. For within‐limb TMS somatotopy, the most common metrics such as the shifts between MCR COGs and hotspots had poor relative reliability. However, overlaps between different muscle MCRs were highly reliable. We, thus, provide novel evidence that inter‐muscle MCR interaction can be reliably traced using MCR overlaps while shifts between the COGs and hotspots of different MCRs are not suitable for this purpose. Our results have implications for the interpretation of nTMS motor mapping results in healthy subjects and patients with neurological conditions.

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Language(s): eng - English
 Dates: 2021-02-092020-09-152021-02-112021-03-082021-06-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.25383
Other: epub 2021
PMID: 33682975
 Degree: -

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Project name : -
Grant ID : 19‐75‐00104
Funding program : -
Funding organization : Russian Science Foundation

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 42 (8) Sequence Number: - Start / End Page: 2508 - 2528 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686