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  Cellular strategies for the assembly of molecular machines

Chari, A., & Fischer, U. (2010). Cellular strategies for the assembly of molecular machines. Trends in biochemical sciences, 35(12), 676-683. doi:10.1016/j.tibs.2010.07.006.

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3292660.pdf (Publisher version), 674KB
 
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 Creators:
Chari, A.1, Author              
Fischer, U., Author
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1Research Group of Structural Biochemistry and Mechanisms, MPI for Biophysical Chemistry, Max Planck Society, ou_3265855              

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 Abstract: Molecular machines are supramolecular assemblies of biomolecules (proteins, RNA and/or DNA) that facilitate a diversity of biological tasks in the cells of all organisms. How these complex structures are built within the crowded cellular environment is, therefore, a central question in the biological sciences. Recent studies on spliceosomal uridine-rich small nuclear ribonucleoproteins (snRNPs) have unveiled cellular assembly strategies for RNA–protein complexes. snRNPs form in vivo by the coordinated action of an elaborate assembly line consisting of assembly chaperones, scaffolding proteins and catalysts. These newly discovered strategies exhibit similarities to those employed by protein complexes such as ribulose-1,5-bisphosphate-carboxylase (Rubisco) and allow the elucidation of general rules for how molecular machines are formed in vivo.

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Language(s): eng - English
 Dates: 2010-08-192010-12
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.tibs.2010.07.006
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Title: Trends in biochemical sciences
Source Genre: Journal
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Pages: - Volume / Issue: 35 (12) Sequence Number: - Start / End Page: 676 - 683 Identifier: -