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  The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Kaya-Copur, A., Marchiano, F., Hein, M. Y., Alpern, D., Russeil, J., Luis, N. M., et al. (2021). The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. eLife, 10: e63726. doi:10.7554/eLife.63726.

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© 2021, Kaya-Çopur et al.

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 Creators:
Kaya-Copur, Aynur1, Author              
Marchiano, Fabio2, Author
Hein, Marco Y.3, Author              
Alpern, Daniel2, Author
Russeil, Julie2, Author
Luis, Nuno Miguel2, Author
Mann, Matthias3, Author              
Deplancke, Bart2, Author
Habermann, Bianca H.2, Author
Schnorrer, Frank1, Author              
Affiliations:
1Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565168              
2external, ou_persistent22              
3Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: CELL-PROLIFERATION; SIGNALING PATHWAY; ADULT MYOGENESIS; TRANSGENIC RNAI; TEAD/TEF FAMILY; FLIGHT MUSCLES; F-ACTIN; DROSOPHILA; PROTEIN; APOPTOSISLife Sciences & Biomedicine - Other Topics;
 Abstract: Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated with growth of the contractile apparatus is not understood. Here, we use the large Drosophila flight muscles to mechanistically decipher how muscle fiber growth is controlled. We find that regulated activity of core members of the Hippo pathway is required to support flight muscle growth. Interestingly, we identify Dlg5 and Slmap as regulators of the STRIPAK phosphatase, which negatively regulates Hippo to enable post-mitotic muscle growth. Mechanistically, we show that the Hippo pathway controls timing and levels of sarcomeric gene expression during development and thus regulates the key components that physically mediate muscle growth. Since Dlg5, STRIPAK and the Hippo pathway are conserved a similar mechanism may contribute to muscle or cardiomyocyte growth in humans.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published online
 Pages: 34
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000611542100001
DOI: 10.7554/eLife.63726
 Degree: -

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Funding program : FP/2007-2013
Funding organization : European Research Council

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 10 Sequence Number: e63726 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X