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  Metabolites of neuroinflammation relate to neuropathic pain after spinal cord injury

Pfyffer, D., Wyss, P. O., Huber, E., Curt, A., Henning, A., & Freund, P. (2020). Metabolites of neuroinflammation relate to neuropathic pain after spinal cord injury. Neurology, 95(7), e805-e814. doi:10.1212/WNL.0000000000010003.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-2B16-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-49FE-4
Genre: Zeitschriftenartikel

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 Urheber:
Pfyffer, Dario1, Autor
Wyss, Patrik O.2, 3, 4, Autor
Huber, Eveline1, Autor
Curt, Armin1, Autor
Henning, Anke2, 4, Autor
Freund, Patrick5, 6, 7, 8, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
3Department of Radiology, Swiss Paraplegic Research (SPF), Nottwill, Switzerland, ou_persistent22              
4Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
5Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA, ou_persistent22              
6Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
7Institute of Neurology, University College London, United Kingdom, ou_persistent22              
8Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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 Zusammenfassung: Objective: To determine whether cervical cord levels of metabolites are associated with pain sensation after spinal cord injury (SCI) by performing magnetic resonance spectroscopy in patients with SCI with and without neuropathic pain (NP).

Methods: Cervical cord single-voxel spectroscopic data of 24 patients with SCI (14 with NP, 10 pain-free) and 21 healthy controls were acquired at C2/3 to investigate metabolite ratios associated with neuroinflammation (choline-containing compounds to myoinositol [tCho/mI]) and neurodegeneration (total N-acetylaspartate to myo-inositol [tNAA/mI]). NP levels were measured, and Spearman correlation tests assessed associations between metabolite levels, cord atrophy, and pinprick score.

Results: In patients with NP, tCho/mI levels were increased (p = 0.024) compared to pain-free patients and negatively related to cord atrophy (p = 0.006, r = 0.714). Better pinprick score was associated with higher tCho/mI levels (p = 0.032, r = 0.574). In pain-free patients, tCho/mI levels were not related to cord atrophy (p = 0.881, r = 0.055) or pinprick score (p = 0.676, r = 0.152). tNAA/mI levels were similar in both patient groups (p = 0.396) and were not associated with pinprick score in patients with NP (p = 0.405, r = 0.242) and pain-free patients (p = 0.117, r = 0.527).

Conclusions: Neuroinflammatory metabolite levels (i.e., tCho/mI) were elevated in patients with NP, its magnitude being associated with less cord atrophy and greater pain sensation (e.g., pinprick score). This suggests that patients with NP have more residual spinal tissue and greater metabolite turnover than pain-free patients. Neurodegenerative metabolite levels (i.e., tNAA/mI) were associated with greater cord atrophy but unrelated to NP. Identifying the metabolic NP signature provides new NP treatment targets and could improve patient stratification in interventional trials.

Classification of evidence: This study provides Class II evidence that levels of magnetic resonance spectroscopy-identified metabolites of neuroinflammation were elevated in patients with SCI with NP compared to those without NP.

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Sprache(n): eng - English
 Datum: 2019-09-242020-01-272020-06-262020-08-18
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1212/WNL.0000000000010003
Anderer: epub 2020
PMID: 32591473
PMC: PMC7605501
 Art des Abschluß: -

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Projektname : -
Grant ID : 143715
Förderprogramm : -
Förderorganisation : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)
Projektname : -
Grant ID : 2047
Förderprogramm : -
Förderorganisation : Hartmann Müller-Stiftung für Medizinische Forschung
Projektname : -
Grant ID : -
Förderprogramm : Clinical Research Priority Program Multiple Sclerosis
Förderorganisation : Universität Zürich
Projektname : SYNAPLAST MR
Grant ID : 679927
Förderprogramm : Horizon 2020
Förderorganisation : European Research Council (ERC)
Projektname : -
Grant ID : WFL-CH-007/14
Förderprogramm : -
Förderorganisation : Wings for Life, Austria
Projektname : -
Grant ID : PCEFP3_181362/1
Förderprogramm : -
Förderorganisation : SNF Eccellenza Professorial Fellowship
Projektname : -
Grant ID : 091593/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust

Quelle 1

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Titel: Neurology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Seiten: - Band / Heft: 95 (7) Artikelnummer: - Start- / Endseite: e805 - e814 Identifikator: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073