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  Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers

Sukenik, N., Vinogradov, O., Weinreb, E., Segal, M., Levina, A., & Moses, E. (2021). Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers. Proceedings of the National Academy of Sciences of the United States of America, 118(12): e2018459118. doi:10.1073/pnas.2018459118.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-2B41-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-000C-B6AE-3
Genre: Zeitschriftenartikel

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https://www.pnas.org/content/pnas/118/12/e2018459118.full.pdf (Verlagsversion)
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 Urheber:
Sukenik, N, Autor
Vinogradov, O1, Autor           
Weinreb, E, Autor
Segal, M, Autor
Levina, A1, Autor           
Moses, E, Autor
Affiliations:
1Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              

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 Zusammenfassung: The interplay between excitation and inhibition is crucial for neuronal circuitry in the brain. Inhibitory cell fractions in the neocortex and hippocampus are typically maintained at 15 to 30%, which is assumed to be important for stable dynamics. We have studied systematically the role of precisely controlled excitatory/inhibitory (E/I) cellular ratios on network activity using mice hippocampal cultures. Surprisingly, networks with varying E/I ratios maintain stable bursting dynamics. Interburst intervals remain constant for most ratios, except in the extremes of 0 to 10% and 90 to 100% inhibitory cells. Single-cell recordings and modeling suggest that networks adapt to chronic alterations of E/I compositions by balancing E/I connectivity. Gradual blockade of inhibition substantiates the agreement between the model and experiment and defines its limits. Combining measurements of population and single-cell activity with theoretical modeling, we provide a clearer picture of how E/I balance is preserved and where it fails in living neuronal networks.

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 Datum: 2021-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1073/pnas.2018459118
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: 9 Band / Heft: 118 (12) Artikelnummer: e2018459118 Start- / Endseite: - Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230