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  DNA methylation predicts age and provides insight into exceptional longevity of bats

Wilkinson, G. S., Adams, D. M., Haghani, A., Lu, A. T., Zoller, J., Breeze, C. E., Arnold, B. D., Ball, H. C., Carter, G. G., Cooper, L. N., Dechmann, D. K. N., Devanna, P., Fasel, N. J., Galazyuk, A. V., Günther, L., Hurme, E., Jones, G., Knörnschild, M., Lattenkamp, E. Z., Li, C. Z., Mayer, F., Reinhardt, J. A., Medellin, R. A., Nagy, M., Pope, B., Power, M. L., Ransome, R. D., Teeling, E. C., Vernes, S. C., Zamora-Mejías, D., Zhang, J., Faure, P. A., Greville, L. J., Herrera M., L. G., Flores-Martínez, J. J., & Horvath, S. (2021). DNA methylation predicts age and provides insight into exceptional longevity of bats. Nature Communications, 12:. doi:10.1038/s41467-021-21900-2.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0008-2C59-4 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000B-13B5-3
資料種別: 学術論文

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Wilkinson_et_al-2021suppl-Nature_Communications.pdf (付録資料), 4MB
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supplementary information
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2021
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Wilkinson_etal_2021_DNA methylation predicts....pdf (出版社版), 4MB
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Wilkinson_etal_2021_DNA methylation predicts....pdf
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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作成者

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 作成者:
Wilkinson, Gerald S.1, 著者
Adams, Danielle M.1, 著者
Haghani, Amin2, 著者
Lu, Ake T.2, 著者
Zoller, Joseph3, 著者
Breeze, Charles E.4, 著者
Arnold, Bryan D.5, 著者
Ball, Hope C.6, 著者
Carter, Gerald G.7, 著者
Cooper, Lisa Noelle6, 著者
Dechmann, Dina K. N.8, 9, 10, 著者
Devanna, Paolo11, 著者           
Fasel, Nicolas J.12, 著者
Galazyuk, Alexander V.6, 著者
Günther, Linus13, 著者
Hurme, Edward1, 9, 著者
Jones, Gareth14, 著者
Knörnschild, Mirjam10, 13, 著者
Lattenkamp, Ella Z.11, 15, 著者
Li, Caesar Z.3, 著者
Mayer, Frieder13, 著者Reinhardt, Josephine A.16, 著者Medellin, Rodrigo A.17, 著者Nagy, Martina13, 著者Pope, Brian18, 著者Power, Megan L.19, 著者Ransome, Roger D.14, 著者Teeling, Emma C.19, 著者Vernes, Sonja C.11, 20, 21, 著者           Zamora-Mejías, Daniel17, 著者Zhang, Joshua2, 著者Faure, Paul A.22, 著者Greville, Lucas J.22, 著者Herrera M. , L. Gerardo17, 著者Flores-Martínez, José J.17, 著者Horvath, Steve2, 3, 著者 全て表示
所属:
1University of Maryland , College Park, MD, USA, ou_persistent22              
2David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA, ou_persistent22              
3University of California, Los Angeles, Los Angeles, CA, USA, ou_persistent22              
4Altius Institute for Biomedical Sciences, Seattle, WA, USA, ou_persistent22              
5Illinois College, Jacksonville, IL, USA, ou_persistent22              
6Northeast Ohio Medical University, Rootstown, OH, USA, ou_persistent22              
7The Ohio State University, Columbus, OH, USA, ou_persistent22              
8Max Planck Institute of Animal Behavior, Radolfzell, Germany, ou_persistent22              
9University of Konstanz, Konstanz, Germany, ou_persistent22              
10Smithsonian Tropical Research Institute, Panama, FL, USA, ou_persistent22              
11Neurogenetics of Vocal Communication Group, MPI for Psycholinguistics, Max Planck Society, ou_2231636              
12University of Lausanne, Lausanne, Switzerland, ou_persistent22              
13Leibniz-Institute for Evolution and Biodiversity Science, Berlin, Germany, ou_persistent22              
14University of Bristol, Bristol, UK, ou_persistent22              
15Ludwig Maximilians University Munich, Martinsried, Germany, ou_persistent22              
16State University of New York, Geneseo, NY, USA, ou_persistent22              
17Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico, ou_persistent22              
18Lubee Bat Conservancy, Gainesville, Gainesville, FL, USA, ou_persistent22              
19University College Dublin, Dublin, Ireland, ou_persistent22              
20Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
21The University of St Andrews, Fife, UK, ou_persistent22              
22McMaster University, Hamilton, Canada, ou_persistent22              

内容説明

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 要旨: Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.

資料詳細

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言語: eng - English
 日付: 2021-03-12
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41467-021-21900-2
 学位: -

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出版物 1

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出版物名: Nature Communications
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: -
ページ: - 巻号: 12 通巻号: 1615 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2041-1723