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  Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior

Julian, J. B., & Doeller, C. F. (2021). Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior. Nature Neuroscience, 24, 863-872. doi:10.1038/s41593-021-00835-3.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-4A57-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-DD8E-C
Genre: Journal Article

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 Creators:
Julian, Joshua B.1, 2, Author
Doeller, Christian F.1, 3, Author           
Affiliations:
1Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
2Princeton Neuroscience Institute, Princeton University, NJ, USA, ou_persistent22              
3Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2591710              

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Free keywords: Adult; Brain Mapping; Entorhinal Cortex; Female; Forecasting; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Spatial Behavior; Virtual Reality; Young Adult
 Abstract: To guide spatial behavior, the brain must retrieve memories that are appropriately associated with different navigational contexts. Contextual memory might be mediated by cell ensembles in the hippocampal formation that alter their responses to changes in context, processes known as remapping and realignment in the hippocampus and entorhinal cortex, respectively. However, whether remapping and realignment guide context-dependent spatial behavior is unclear. To address this issue, human participants learned object–location associations within two distinct virtual reality environments and subsequently had their memory tested during functional MRI (fMRI) scanning. Entorhinal grid-like representations showed realignment between the two contexts, and coincident changes in fMRI activity patterns consistent with remapping were observed in the hippocampus. Critically, in a third ambiguous context, trial-by-trial remapping and realignment in the hippocampal–entorhinal network predicted context-dependent behavior. These results reveal the hippocampal–entorhinal mechanisms mediating human contextual memory and suggest that the hippocampal formation plays a key role in spatial behavior under uncertainty.

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Language(s): eng - English
 Dates: 2019-11-252021-03-082021-04-152021-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41593-021-00835-3
Other: epub 2021
PMID: 33859438
 Degree: -

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Project name : -
Grant ID : ERC-CoG GEOCOG 724836
Funding program : Horizon 2020 Framework Programme
Funding organization : European Research Council (ERC), European Commission
Project name : CELLEX
Grant ID : -
Funding program : -
Funding organization : Max Planck Society Foundation
Project name : -
Grant ID : NWO-Vidi 452-12-009
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Kavli Foundation
Project name : -
Grant ID : 223262/F50
Funding program : -
Funding organization : Centre of Excellence scheme of the Research Council of Norway - Centre for Neural Computation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Project name : -
Grant ID : 197467/F50
Funding program : NORBRAIN
Funding organization : National Infrastructure scheme of the Research Council of Norway
Project name : -
Grant ID : -
Funding program : -
Funding organization : Norwegian University of Science and Technology (NTNU)
Project name : -
Grant ID : -
Funding program : H2020 Excellent Science
Funding organization : -

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 24 Sequence Number: - Start / End Page: 863 - 872 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931