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Abstract:
During oogenesis Xenopus oocytes accumulate a large stockpile of Na+/K+-pump molecules (10) consisting of al and ß3 subunits (7). Fully-grown oocytes continue to synthesize significant amounts of al subunits, but the formation of new α1/ß3 complexes is strictly limited by a very low level of synthesis of endogenous ß3 subunits (1). The al subunits that fail to find a ß3 subunit are maintained in an assembly-competent form (1) and can be rescued to leave the endoplasmic reticulum (ER) by pairing with exogenous ß1 subunits synthesized later from injected cRNAs (9).