Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development

Schoels, M., Zhuang, M., Fahrner, A., Kuechlin, S., Sagar, S., Franz, H., et al. (2021). Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development. American Journal of Physiology-Renal Physiology, 320, F826-F837. doi: 10.1152/ajprenal.00610.2020.

Item is

 

einblenden: alle

Basisdaten

ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-32D2-2 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000A-2E91-F
Genre: Zeitschriftenartikel

Dateien

ausblenden: Dateien
:
Schoels et al. 2021.pdf (Verlagsversion), 10MB
 
Datei-Permalink:
-
Name:
Schoels et al. 2021.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
2021
Copyright Info:
the American Physiological Society
Lizenz:
-

Externe Referenzen

ausblenden:
externe Referenz:
https://journals.physiology.org/doi/abs/10.1152/ajprenal.00610.2020 (Verlagsversion)
Beschreibung:
-
OA-Status:

Urheber

ausblenden:
 Urheber:
Schoels, Maximilian1, Autor
Zhuang, Mingyue1, Autor
Fahrner, Andreas1, Autor
Kuechlin, Sebastian1, Autor
Sagar, Sagar2, Autor
Franz, Henriette1, Autor
Schmitt, Annette1, Autor
Walz, Gerd1, Autor
Yakulov, Toma Antonov1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_persistent22              

Inhalt

ausblenden:
Schlagwörter: pronephros; single-cell RNA sequencing; zebrafish
 Zusammenfassung: Developing organisms need to adapt to environmental variations as well as to rapid changes in substrate availability and energy demands imposed by fast-growing tissues and organs. Little is known about the adjustments that kidneys undergo in response to these challenges. We performed single-cell RNA sequencing of zebrafish pronephric duct cells to understand how the developing kidney responds to changes in filtered substrates and intrinsic energy requirements. We found high levels of glucose transporters early in development and increased expression of monocarboxylate transporters at later times. This indicates that the zebrafish embryonal kidney displays a high glucose transporting capacity during early development, which is replaced by the ability to absorb monocarboxylates and amino acids at later stages. This change in transport capacity was accompanied by upregulation of mitochondrial carriers, indicating a switch to increased oxidative phosphorylation to meet the increasing energy demand of a developing kidney.

Details

ausblenden:
Sprache(n): eng - English
 Datum: 2021-03-22
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1152/ajprenal.00610.2020
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

ausblenden:
Titel: American Journal of Physiology-Renal Physiology
  Andere : Am. J. Physiol. Renal Physiol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Bethesda, Md. : American Physiological Society.
Seiten: - Band / Heft: 320 Artikelnummer: - Start- / Endseite: F826 - F837 Identifikator: ISSN: 0363-6127
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000238890