Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Wettstein, Lukas; Weil, Tanja; Conzelmann, Carina; Müller, Janis A.; Gross, Rüdiger; Hirschenberger, Maximilian; Seidel, Alina; Klute, Susanne; Zech, Fabian; Bozzo, Caterina Prelli; Preising, Nico; Fois, Giorgio; Lochbaum, Robin; Knaff, Philip Maximilian; Mailänder, Volker; Staendker, Ludger; Thal, Dietmar Rudolf; Schumann, Christian; Stenger, Steffen; Kleger, Alexander; Lochnit, Günter; Mayer, Benjamin; Ruiz-Blanco, Yasser B.; Hoffmann, Markus; Sparrer, Konstantin M. J.; Poehlmann, Stefan; Sanchez-Garcia, Elsa; Kirchhoff, Frank; Frick, Manfred; Muench, Jan

doi:10.1038/s41467-021-21972-0

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Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Wettstein, L., Weil, T., Conzelmann, C., Müller, J. A., Gross, R., Hirschenberger, M., et al. (2021). Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. Nature Communications, 12: 1726. doi:10.1038/s41467-021-21972-0.

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Creators:
Wettstein, Lukas¹, Author
Weil, Tanja¹, Author
Conzelmann, Carina¹, Author
Müller, Janis A.¹, Author
Gross, Rüdiger¹, Author
Hirschenberger, Maximilian¹, Author
Seidel, Alina¹, Author
Klute, Susanne¹, Author
Zech, Fabian¹, Author
Bozzo, Caterina Prelli¹, Author
Preising, Nico², Author
Fois, Giorgio³, Author
Lochbaum, Robin³, Author
Knaff, Philip Maximilian^{4, 5}, Author
Mailänder, Volker^{4, 5}, Author
Staendker, Ludger², Author
Thal, Dietmar Rudolf^{6, 7, 8}, Author
Schumann, Christian^{9, 10}, Author
Stenger, Steffen¹¹, Author
Kleger, Alexander¹², Author
Lochnit, Günter¹³, AuthorMayer, Benjamin¹⁴, AuthorRuiz-Blanco, Yasser B.¹⁵, AuthorHoffmann, Markus^{16, 17}, AuthorSparrer, Konstantin M. J.¹, AuthorPoehlmann, Stefan¹⁶, AuthorSanchez-Garcia, Elsa¹⁵, AuthorKirchhoff, Frank¹, AuthorFrick, Manfred³, AuthorMuench, Jan^{1, 2}, Author more..

Affiliations:
1Ulm Univ, Inst Mol Virol, Med Ctr, Ulm, Germany, ou_persistent22
2Ulm Univ, Core Facil Funct Peptid, Med Ctr, Ulm, Germany, ou_persistent22
3Ulm Univ, Inst Gen Physiol, Ulm, Germany, ou_persistent22
4Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany, ou_persistent22
5Dept. Landfester: Physical Chemistry of Polymers, MPI for Polymer Research, Max Planck Society, ou_1800288
6Katholieke Univ Leuven, Dept Imaging & Pathol, Lab Neuropathol, Leuven, Belgium, ou_persistent22
7UZ Leuven, Dept Pathol, Leuven, Belgium, ou_persistent22
8Ulm Univ, Inst Pathol, Lab Neuropathol, Ulm, Germany, ou_persistent22
9Clin Allgau, Pneumol Thorac Oncol Sleep & Resp Crit Care Med, Kempten, Germany, ou_persistent22
10‎Clin Allgau, Pneumol Thorac Oncol Sleep & Resp Crit Care Med, Immenstadt, Germany, ou_persistent22
11Ulm Univ, Inst Microbiol & Hyg, Med Ctr, Ulm, Germany, ou_persistent22
12Ulm Univ Hosp, Dept Internal Med 1, Ulm, Germany, ou_persistent22
13Justus Liebig Univ Giessen, Inst Biochem, Giessen, Germany, ou_persistent22
14Ulm Univ, Inst Epidemiol & Med Biometry, Ulm, Germany, ou_persistent22
15Univ Duisburg Essen, Ctr Med Biotechnol, Computat Biochem, Essen, Germany, ou_persistent22
16German Primate Ctr, Infect Biol Unit, Leibniz Inst Primate Res, Gottingen, Germany, ou_persistent22
17Georg August Univ, Fac Biol & Psychol, Gottingen, Germany, ou_persistent22

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Language(s): eng - English

Dates: Published Online: 2021-03-19

Publication Status: Published online

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Identifiers: DOI: 10.1038/s41467-021-21972-0

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Title: Nature Communications

Abbreviation : Nat. Commun.

Source Genre: Journal

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Publ. Info: London : Nature Publishing Group

Pages: - Volume / Issue: 12 Sequence Number: 1726 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723