Structure-function studies on gastrointestinal hormones: I. Synthesis of 
secretin analogs and their biological and immunological properties

Moroder, Luis; Jaeger, Ernst; Drees, Fritz; Gemeiner, Manfred; Knof, Siegward; Stelzel, Hans-Peter; Thamm, Paul; Bataille, Dominique; Domschke, Sigurd; Schlegel, Werner; Schulz, Irene; Wünsch, Erich

doi:10.1016/0045-2068(80)90031-0

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Structure-function studies on gastrointestinal hormones: I. Synthesis of secretin analogs and their biological and immunological properties

Moroder, L., Jaeger, E., Drees, F., Gemeiner, M., Knof, S., Stelzel, H.-P., et al. (1980). Structure-function studies on gastrointestinal hormones: I. Synthesis of secretin analogs and their biological and immunological properties. Bioorganic Chemistry, 9(1), 27-54. doi:10.1016/0045-2068(80)90031-0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-40FC-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-40FD-3

Genre: Journal Article

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Creators:
Moroder, Luis¹, Author
Jaeger, Ernst¹, Author
Drees, Fritz¹, Author
Gemeiner, Manfred¹, Author
Knof, Siegward¹, Author
Stelzel, Hans-Peter¹, Author
Thamm, Paul¹, Author
Bataille, Dominique², Author
Domschke, Sigurd³, Author
Schlegel, Werner⁴, Author
Schulz, Irene⁵, Author
Wünsch, Erich¹, Author

Affiliations:
1Max-Planck-Institut für Biochemie, Abteilung Peptidchemie, Martinsried, Federal Republic of Germany, ou_persistent22
2D. Bataille, Batiment INSERM, Hopital Saint-Antoine, Paris, France, ou_persistent22
3Department of Medicine, University of Erlangen-Nürnberg, Erlangen, Federal Republic of Germany, ou_persistent22
4Department of Internal Medicine, University of Ulm, Ulm, Federal Republic of Germany, ou_persistent22
5Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297

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Abstract: Syntheses by conventional procedures of the three analogs corresponding to the porcine secretin sequence crossed at position 6 by the N-terminal hexapeptide sequences of VIP, GIP, and glucagon are described, viz., Ala⁴,Val⁵-, Tyr¹,Ala²,Glu³-, and Gln³-secretin (VIP-SN, GIP-SN, and GLU-SN). The analog Phe¹,Phe²,Trp³,Lys⁴-secretin (SOMA-SN), designed on the basis of the surprising homology of the sequence portions 10–13 of somatostatin and 5–8 of secretin, was also prepared. Finally, the synthesis of N^α-3-(4-hydroxyphenyl)propionyl-β-alanyl-secretin (DATA-SN), a tracer suitable for secretin radioimmunoassay and as an N-terminus modified secretin analog, is reported. The analogs are compared, in terms of their biological and immunological properties in different assay systems, with pure synthetic secretin.

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Language(s): eng - English

Dates: Submitted: 1979-02-16Published Online: 2004-05-24Date issued: 1980-03-01

Publication Status: Issued

Pages: 28

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Rev. Type: Peer

Identifiers: DOI: 10.1016/0045-2068(80)90031-0

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Title: Bioorganic Chemistry

Source Genre: Journal

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Publ. Info: San Diego, Calif. : Elsevier

Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 27 - 54 Identifier: ISSN: 0045-2068
CoNE: https://pure.mpg.de/cone/journals/resource/0045-2068