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  Emergence of local and global synaptic organization on cortical dendrites.

Kirchner, J. H., & Gjorgjieva, J. (2021). Emergence of local and global synaptic organization on cortical dendrites. Nat. Commun., 12: 4005. doi:10.1038/s41467-021-23557-3.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-4682-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-E92E-F
Genre: Journal Article

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https://pubmed.ncbi.nlm.nih.gov/34183661/ (Any fulltext)
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 Creators:
Kirchner, Jan H.1, 2, Author
Gjorgjieva, Julijana1, 2, Author           
Affiliations:
1Computation in Neural Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_2461694              
2School of Life Sciences, Technical University of Munich, Freising, Germany, ou_persistent22              

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 Abstract: Synaptic inputs on cortical dendrites are organized with remarkable subcellular precision at the micron level. This organization emerges during early postnatal development through patterned spontaneous activity and manifests both locally where nearby synapses are significantly correlated, and globally with distance to the soma. We propose a biophysically motivated synaptic plasticity model to dissect the mechanistic origins of this organization during development and elucidate synaptic clustering of different stimulus features in the adult. Our model captures local clustering of orientation in ferret and receptive field overlap in mouse visual cortex based on the receptive field diameter and the cortical magnification of visual space. Including action potential back-propagation explains branch clustering heterogeneity in the ferret and produces a global retinotopy gradient from soma to dendrite in the mouse. Therefore, by combining activity-dependent synaptic competition and species-specific receptive fields, our framework explains different aspects of synaptic organization regarding stimulus features and spatial scales.

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Language(s): eng - English
 Dates: 2021-02-192021-05-032021-06-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-23557-3
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Project name : Spontaneous and sensory-evoked activity shape neural circuits in the developing brain (NeuroDevo)
Grant ID : 804824
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : Activity-dependent fine-scale organization of functional synaptic inputs in developing neurons
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Funding program : -
Funding organization : Behrens-Weise-Stiftung
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Grant ID : -
Funding program : SMART START training program in computational neuroscience
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Title: Nat. Commun.
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 12 Sequence Number: 4005 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723