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Abstract:
Plasma membranes were isolated from rat kidney and their transport properties for sodium, calcium, protons, phosphate, glucose, lactate, and phenylalanine were investigated. The results demonstrate that the luminal plasma membrane, which is in contact with the primary urine, and the contraluminal plasma membrane, which is in contact with the interstitial fluid, differ in their content of ion-sensitive ATPases and sodium-cotransport systems. This allows conclusions on the mechanism of renal transport in which luminal and contraluminal membranes are arranged functionally in series.
