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  Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats

Hasanpour, M., Mitricheva, E., Logothetis, N., & Noori, H. (2021). Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats. Cell Reports, 35(2): 108987, pp. 1-21. doi:10.1016/j.celrep.2021.108987.

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Hasanpour, M1, 2, Autor           
Mitricheva, E1, 2, Autor           
Logothetis, NK2, 3, Autor           
Noori, HR1, 2, Autor           
Affiliations:
1Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: Rats have been used as animal models for human diseases for more than a century, yet a systematic understanding of basal biobehavioral phenotypes of laboratory rats is still missing. In this study, we utilize wireless tracking technology and videography, collect and analyze more than 130 billion data points to fill this gap, and characterize the evolution of behavior and physiology of group-housed male and female rats (n = 114) of the most commonly used strains (Lister Hooded, Long-Evans, Sprague-Dawley, and Wistar) throughout their development. The resulting intensive longitudinal data suggest the existence of strain and sex differences and bi-stable developmental states. Under standard laboratory 12-h light/12-h dark conditions, our study found the presence of multiple oscillations such as circatidal-like rhythms in locomotor activity. The overall findings further suggest that frequent movement along cage walls or thigmotaxic activity may be a physical feature of motion in constrained spaces, critically affecting the interpretation of basal behavior of rats in cages.

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 Datum: 2021-04
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1016/j.celrep.2021.108987
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Titel: Cell Reports
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Maryland Heights, MO : Cell Press
Seiten: - Band / Heft: 35 (2) Artikelnummer: 108987 Start- / Endseite: 1 - 21 Identifikator: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247