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  Discovery of oligosaccharide antigens for semi-synthetic glycoconjugate vaccine leads against Streptococcus suis serotypes 2, 3, 9 and 14

Zhang, S., Sella, M., Sianturi, J., Priegue, P., Shen, D., & Seeberger, P. H. (2021). Discovery of oligosaccharide antigens for semi-synthetic glycoconjugate vaccine leads against Streptococcus suis serotypes 2, 3, 9 and 14. Angewandte Chemie International Edition, 60(26), 14679-14692. doi:10.1002/anie.202103990.

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 Creators:
Zhang, Shuo1, Author              
Sella, Mauro1, Author              
Sianturi, Julinton1, Author              
Priegue, Patricia1, Author              
Shen, Dacheng1, Author              
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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Free keywords: carbohydrates, immunology, glycans, oligosaccharides, total synthesis
 Abstract: Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotype 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotype 2 and 9 glycoconjugate veterinary vaccines were identified in this way.

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Language(s): eng - English
 Dates: 2021-04-142021
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1002/anie.202103990
DOI: 10.1002/ange.202103990
BibTex Citekey: https://doi.org/10.1002/anie.202103990
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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 60 (26) Sequence Number: - Start / End Page: 14679 - 14692 Identifier: ISSN: 1433-7851

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Title: Angewandte Chemie
  Abbreviation : Angew. Chem.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 133 (26) Sequence Number: - Start / End Page: 14800 - 14813 Identifier: ISSN: 0044-8249