English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI

Sanchez Panchuelo, R. M., Mougin, O., Turner, R., & Francis, S. T. (2021). Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI. NeuroImage, 234: 117976. doi:10.1016/j.neuroimage.2021.117976.

Item is

Files

show Files
hide Files
:
Panchuelo_2021.pdf (Publisher version), 6MB
Name:
Panchuelo_2021.pdf
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Sanchez Panchuelo, Rosa M.1, 2, Author
Mougin, Olivier1, Author
Turner, Robert1, 3, Author           
Francis, Susan T.1, 2, Author
Affiliations:
1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              
2NIHR Nottingham Biomedical Research Centre, University of Nottingham, United Kingdom, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

Content

show
hide
Free keywords: Structural MRI; Quantitative T1 mapping; Multi-slice IR‑EPI; Fat suppression; Neuroanatomy
 Abstract: An efficient multi-slice inversion–recovery EPI (MS-IR-EPI) sequence for fast, high spatial resolution, quantitative T1 mapping is presented, using a segmented simultaneous multi-slice acquisition, combined with slice order shifting across multiple acquisitions. The segmented acquisition minimises the effective TE and readout duration compared to a single-shot EPI scheme, reducing geometric distortions to provide high quality T1 maps with a narrow point-spread function. The precision and repeatability of MS-IR-EPI T1 measurements are assessed using both T1-calibrated and T2-calibrated ISMRM/NIST phantom spheres at 3 and 7 T and compared with single slice IR and MP2RAGE methods. Magnetization transfer (MT) effects of the spectrally-selective fat-suppression (FS) pulses required for in vivo imaging are shown to shorten the measured in-vivo T1 values. We model the effect of these fat suppression pulses on T1 measurements and show that the model can remove their MT contribution from the measured T1, thus providing accurate T1 quantification. High spatial resolution T1 maps of the human brain generated with MS-IR-EPI at 7 T are compared with those generated with the widely implemented MP2RAGE sequence. Our MS-IR-EPI sequence provides high SNR per unit time and sharper T1 maps than MP2RAGE, demonstrating the potential for ultra-high resolution T1 mapping and the improved discrimination of functionally relevant cortical areas in the human brain.

Details

show
hide
Language(s): eng - English
 Dates: 2021-02-272020-07-232021-03-132021-03-262021-07-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021.117976
Other: epub 2021
PMID: 33781969
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : MR/M022722/1
Funding program : -
Funding organization : UK Medical Research Council (MRC)

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 234 Sequence Number: 117976 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166