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  Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays

Schmidt, H., Hahn, G., Deco, G., & Knösche, T. R. (2021). Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays. PLoS Computational Biology, 17(2): e1007858. doi:10.1371/journal.pcbi.1007858.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-5422-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-1458-A
Genre: Journal Article

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 Creators:
Schmidt, Helmut1, Author           
Hahn, Gerald2, Author
Deco, Gustavo2, 3, 4, 5, Author           
Knösche, Thomas R.1, 6, Author                 
Affiliations:
1Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              

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 Abstract: Axonal connections are widely regarded as faithful transmitters of neuronal signals with fixed delays. The reasoning behind this is that extracellular potentials caused by spikes travelling along axons are too small to have an effect on other axons. Here we devise a computational framework that allows us to study the effect of extracellular potentials generated by spike volleys in axonal fibre bundles on axonal transmission delays. We demonstrate that, although the extracellular potentials generated by single spikes are of the order of microvolts, the collective extracellular potential generated by spike volleys can reach several millivolts. As a consequence, the resulting depolarisation of the axonal membranes increases the velocity of spikes, and therefore reduces axonal delays between brain areas. Driving a neural mass model with such spike volleys, we further demonstrate that only ephaptic coupling can explain the reduction of stimulus latencies with increased stimulus intensities, as observed in many psychological experiments.

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Language(s): eng - English
 Dates: 2020-04-022020-10-062021-02-08
 Publication Status: Published online
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pcbi.1007858
Other: eCollection 2021
PMID: 33556058
PMC: PMC7895385
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Grant ID : KN 588/7-1; DE 832/1-1
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Funding organization : German Research Council (DFG)
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Grant ID : PID2019-105772GB-I00 AEI FEDER EU
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Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU)
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Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union
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Funding organization : State Research Agency (AEI)
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Funding organization : European Regional Development Funds (FEDER)
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Funding organization : Catalan Agency for Management of University and Research Grants (AGAUR)

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Title: PLoS Computational Biology
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 17 (2) Sequence Number: e1007858 Start / End Page: - Identifier: ISSN: 1553-734X
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180_1