Ephaptic coupling in white matter fibre bundles modulates axonal transmission 
delays

Schmidt, Helmut; Hahn, Gerald; Deco, Gustavo; Knösche, Thomas R.

doi:10.1371/journal.pcbi.1007858

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Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays

Schmidt, H., Hahn, G., Deco, G., & Knösche, T. R. (2021). Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays. PLoS Computational Biology, 17(2): e1007858. doi:10.1371/journal.pcbi.1007858.

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Urheber:
Schmidt, Helmut¹, Autor
Hahn, Gerald², Autor
Deco, Gustavo^{2, 3, 4, 5}, Autor
Knösche, Thomas R.^{1, 6}, Autor

Affiliations:
1Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22
3Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551
6Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22

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Zusammenfassung: Axonal connections are widely regarded as faithful transmitters of neuronal signals with fixed delays. The reasoning behind this is that extracellular potentials caused by spikes travelling along axons are too small to have an effect on other axons. Here we devise a computational framework that allows us to study the effect of extracellular potentials generated by spike volleys in axonal fibre bundles on axonal transmission delays. We demonstrate that, although the extracellular potentials generated by single spikes are of the order of microvolts, the collective extracellular potential generated by spike volleys can reach several millivolts. As a consequence, the resulting depolarisation of the axonal membranes increases the velocity of spikes, and therefore reduces axonal delays between brain areas. Driving a neural mass model with such spike volleys, we further demonstrate that only ephaptic coupling can explain the reduction of stimulus latencies with increased stimulus intensities, as observed in many psychological experiments.

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Sprache(n): eng - English

Datum: Eingereicht: 2020-04-02Angenommen: 2020-10-06Online veröffentlicht: 2021-02-08

Publikationsstatus: Online veröffentlicht

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Identifikatoren: DOI: 10.1371/journal.pcbi.1007858
Anderer: eCollection 2021
PMID: 33556058
PMC: PMC7895385

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Grant ID : KN 588/7-1; DE 832/1-1

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Förderorganisation : German Research Council (DFG)

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Grant ID : PID2019-105772GB-I00 AEI FEDER EU

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Förderorganisation : Spanish Ministry of Science, Innovation and Universities (MCIU)

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Grant ID : 945539

Förderprogramm : Horizon 2020

Förderorganisation : European Union

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Förderorganisation : State Research Agency (AEI)

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Förderorganisation : European Regional Development Funds (FEDER)

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Förderorganisation : Catalan Agency for Management of University and Research Grants (AGAUR)

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Titel: PLoS Computational Biology

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: San Francisco, CA : Public Library of Science

Seiten: - Band / Heft: 17 (2) Artikelnummer: e1007858 Start- / Endseite: - Identifikator: ISSN: 1553-734X
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180_1

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