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  Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays

Schmidt, H., Hahn, G., Deco, G., & Knösche, T. R. (2021). Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays. PLoS Computational Biology, 17(2):. doi:10.1371/journal.pcbi.1007858.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0008-5422-3 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-1458-A
資料種別: 学術論文

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Schmidt_2021.pdf (出版社版), 3MB
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https://hdl.handle.net/21.11116/0000-0008-5424-1
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Schmidt_2021.pdf
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Gold
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application/pdf / [MD5]
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作成者

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 作成者:
Schmidt, Helmut1, 著者           
Hahn, Gerald2, 著者
Deco, Gustavo2, 3, 4, 5, 著者           
Knösche, Thomas R.1, 6, 著者                 
所属:
1Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              

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 要旨: Axonal connections are widely regarded as faithful transmitters of neuronal signals with fixed delays. The reasoning behind this is that extracellular potentials caused by spikes travelling along axons are too small to have an effect on other axons. Here we devise a computational framework that allows us to study the effect of extracellular potentials generated by spike volleys in axonal fibre bundles on axonal transmission delays. We demonstrate that, although the extracellular potentials generated by single spikes are of the order of microvolts, the collective extracellular potential generated by spike volleys can reach several millivolts. As a consequence, the resulting depolarisation of the axonal membranes increases the velocity of spikes, and therefore reduces axonal delays between brain areas. Driving a neural mass model with such spike volleys, we further demonstrate that only ephaptic coupling can explain the reduction of stimulus latencies with increased stimulus intensities, as observed in many psychological experiments.

資料詳細

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言語: eng - English
 日付: 2020-04-022020-10-062021-02-08
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): DOI: 10.1371/journal.pcbi.1007858
その他: eCollection 2021
PMID: 33556058
PMC: PMC7895385
 学位: -

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Project information

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Project name : -
Grant ID : KN 588/7-1; DE 832/1-1
Funding program : -
Funding organization : German Research Council (DFG)
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Grant ID : PID2019-105772GB-I00 AEI FEDER EU
Funding program : -
Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU)
Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union
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Funding organization : State Research Agency (AEI)
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Funding organization : European Regional Development Funds (FEDER)
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Funding program : -
Funding organization : Catalan Agency for Management of University and Research Grants (AGAUR)

出版物 1

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出版物名: PLoS Computational Biology
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: San Francisco, CA : Public Library of Science
ページ: - 巻号: 17 (2) 通巻号: e1007858 開始・終了ページ: - 識別子(ISBN, ISSN, DOIなど): ISSN: 1553-734X
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180_1