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  Functional specialization within the inferior parietal lobes across cognitive domains

Numssen, O., Bzdok, D., & Hartwigsen, G. (2021). Functional specialization within the inferior parietal lobes across cognitive domains. eLife, 10: e63591. doi:10.7554/eLife.63591.

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 Creators:
Numssen, Ole1, Author              
Bzdok, Danilo2, 3, Author
Hartwigsen, Gesa1, Author              
Affiliations:
1Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
2McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
3Mila – Quebec Artificial Intelligence Institute, Montréal, QC, Canada , ou_persistent22              

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Free keywords: Attention; Human; Human cognition; Human intelligence; Language; Lateralization; Neuroscience; Systems neuroscience
 Abstract: The inferior parietal lobe (IPL) is a key neural substrate underlying diverse mental processes, from basic attention to language and social cognition, that define human interactions. Its putative domain-global role appears to tie into poorly understood differences between cognitive domains in both hemispheres. Across attentional, semantic, and social cognitive tasks, our study explored functional specialization within the IPL. The task specificity of IPL subregion activity was substantiated by distinct predictive signatures identified by multivariate pattern-learning algorithms. Moreover, the left and right IPL exerted domain-specific modulation of effective connectivity among their subregions. Task-evoked functional interactions of the anterior and posterior IPL subregions involved recruitment of distributed cortical partners. While anterior IPL subregions were engaged in strongly lateralized coupling links, both posterior subregions showed more symmetric coupling patterns across hemispheres. Our collective results shed light on how under-appreciated hemispheric specialization in the IPL supports some of the most distinctive human mental capacities.

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Language(s): eng - English
 Dates: 2020-09-302020-03-012021-03-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.63591
PMID: 33650486
PMC: PMC7946436
 Degree: -

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Project name : -
Grant ID : BZ2/4-1; BZ2/3-1; BZ2/2-1; HA6314/3-1; HA6314/4-1
Funding program : -
Funding organization : German Research Foundation
Project name : -
Grant ID : R01AG068563A
Funding program : -
Funding organization : National Institutes of Health

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 10 Sequence Number: e63591 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X