English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Quantifying progression in primary progressive aphasia with structural neuroimaging

Lombardi, J., Mayer, B., Semler, E., Anderl‐Straub, S., Uttner, I., Kassubek, J., et al. (2021). Quantifying progression in primary progressive aphasia with structural neuroimaging. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. doi:10.1002/alz.12323.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Lombardi_2021.pdf (Publisher version), 8MB
Name:
Lombardi_2021.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Lombardi, Jolina, Author
Mayer, Benjamin, Author
Semler, Elisa, Author
Anderl‐Straub, Sarah, Author
Uttner, Ingo, Author
Kassubek, Jan, Author
Diehl‐Schmid, Janine, Author
Danek, Adrian, Author
Levin, Johannes, Author
Fassbender, Klaus, Author
Fliessbach, Klaus, Author
Schneider, Anja, Author
Huppertz, Hans‐Jürgen, Author
Jahn, Holger, Author
Volk, Alexander, Author
Kornhuber, Johannes, Author
Landwehrmeyer, Bernhard, Author
Lauer, Martin, Author
Prudlo, Johannes, Author
Wiltfang, Jens, Author
Schroeter, Matthias L.1, Author              Ludolph, Albert, AuthorOtto, Markus, Author more..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Atlas-based volumetry; Disease progression; Frontotemporal dementia; Longitudinal magnetic resonance imaging; Primary progressive aphasia; Sample size calculation
 Abstract: Introduction: The term primary progressive aphasia (PPA) sums up the non-fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods: Structural brain imaging and an extensive assessment were applied at baseline and up to 4-year(s) follow-up in 269 participants. With automated atlas-based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results: At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (-17%) and of the left temporal lobe for svPPA (-34%) and lvPPA (-24%). Severest progression within 1-year follow-up occurred in the basal ganglia in nfvPPA (-7%), in the hippocampus/amygdala in svPPA (-9%), and in (medial) temporal regions in lvPPA (-6%). Conclusion: PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.

Details

show
hide
Language(s): eng - English
 Dates: 2021-01-222020-10-122021-01-312021-03-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/alz.12323
Other: online ahead of print
PMID: 33787063
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : FKZ01GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research
Project name : Neurodegenerative Disease Research
Grant ID : 01ED1512
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : D.3830, D.5009
Funding program : -
Funding organization : Baden-Württemberg
Project name : -
Grant ID : SCHR 774/5‐1
Funding program : -
Funding organization : German Research Foundation

Source 1

show
hide
Title: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 2352-8729
CoNE: https://pure.mpg.de/cone/journals/resource/2352-8729