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  Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

Amorim-de-Sousa, A., Schilling, T., Fernandes, P., Seshadri, Y., Bahmani, H., & González-Méijome, J. (2021). Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes. Scientific Reports, 11(1): 9273, pp. 1-10. doi:10.1038/s41598-021-88459-2.

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Amorim-de-Sousa, A, Author
Schilling, T, Author
Fernandes, P, Author
Seshadri, Y, Author
Bahmani, H1, 2, Author              
González-Méijome, JM, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for 'Time after stimulation' (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.

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 Dates: 2021-04
 Publication Status: Published online
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 Identifiers: DOI: 10.1038/s41598-021-88459-2
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 11 (1) Sequence Number: 9273 Start / End Page: 1 - 10 Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322