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  Analysis of patchclamp recordings: model-free multiscale methods and software

Pein, F., Eltzner, B., & Munk, A. (2021). Analysis of patchclamp recordings: model-free multiscale methods and software. European Biophysics Journal, 50(2), 187-209. doi:10.1007/s00249-021-01506-8.

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 Creators:
Pein, F., Author
Eltzner, B., Author
Munk, A.1, Author              
Affiliations:
1Research Group of Statistical Inverse-Problems in Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_1113580              

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Free keywords: Deconvolution; Flickering; Fully automatic; Hidden Markov models; Homogeneous and heterogeneous noise; Ion channel recordings; Low-pass filtering; Open-channel noise; PorB; Subconductance states
 Abstract: Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free multiscale idealization methodology JSMURF, JULES, and HILDE. We provide an operational manual how to use the accompanying software available as an R-package and as a graphical user interface. This includes selection of the right approach and tuning of parameters. We also discuss advantages and disadvantages of model-free approaches in comparison to hidden Markov model approaches and explain how they complement each other.

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Language(s): eng - English
 Dates: 2021-04-092021-03
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00249-021-01506-8
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Title: European Biophysics Journal
Source Genre: Journal
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Pages: - Volume / Issue: 50 (2) Sequence Number: - Start / End Page: 187 - 209 Identifier: -