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  TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

Chen, J., He, R., Sun, W., Gao, R., Peng, Q., Zhu, L., et al. (2020). TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response. Nature Communications, 11: 1913. doi:10.1038/s41467-020-15564-7.

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 Creators:
Chen, Jianwen , Author
He, Ruirui , Author
Sun, Wanwei, Author
Gao, Ru, Author
Peng, Qianwen , Author
Zhu, Liwen, Author
Du, Yanyun, Author
Ma, Xiaojian, Author
Guo, Xiaoli , Author
Zhang, Huazhi , Author
Tan, Chengcheng, Author
Wang, Junhan, Author
Zhang, Wei, Author
Weng, Xiufang , Author
Man, Jianghong, Author
Bauer, Hermann1, Author              
Wang, Qing K. , Author
Martin, Bradley N. , Author
Zhang, Cun-Jin , Author
Li, Xiaoxia, Author
Wang, Chenhui, Author more..
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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Free keywords: Antimicrobial responses Fungal infection Multiple sclerosis Pattern recognition receptors Signal transduction
 Abstract: The TAGAP gene locus has been linked to several infectious diseases or autoimmune diseases, including candidemia and multiple sclerosis. While previous studies have described a role of TAGAP in T cells, much less is known about its function in other cell types. Here we report that TAGAP is required for Dectin-induced anti-fungal signaling and proinflammatory cytokine production in myeloid cells. Following stimulation with Dectin ligands, TAGAP is phosphorylated by EPHB2 at tyrosine 310, which bridges proximal Dectin-induced EPHB2 activity to downstream CARD9-mediated signaling pathways. During Candida albicans infection, mice lacking TAGAP mount defective immune responses, impaired Th17 cell differentiation, and higher fungal burden. Similarly, in experimental autoimmune encephalomyelitis model of multiple sclerosis, TAGAP deficient mice develop significantly attenuated disease. In summary, we report that TAGAP plays an important role in linking Dectin-induced signaling to the promotion of effective T helper cell immune responses, during both anti-fungal host defense and autoimmunity.

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Language(s): eng - English
 Dates: 2020-03-122020-04-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41467-020-15564-7
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 11 Sequence Number: 1913 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723