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  Gradient of electro-convulsive therapy’s antidepressant effects along the longitudinal hippocampal axis

Gyger, L., Regen, F., Ramponi, C., Marquis, R., Mall, J.-F., Swierkosz-Lenart, K., et al. (2021). Gradient of electro-convulsive therapy’s antidepressant effects along the longitudinal hippocampal axis. Translational Psychiatry, 11: 191. doi:10.1038/s41398-021-01310-0.

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 Creators:
Gyger, Lucien1, Author
Regen, Francesca2, Author
Ramponi, Cristina1, Author
Marquis, Renaud3, Author
Mall, Jean-Frederic4, Author
Swierkosz-Lenart, Kevin4, Author
von Gunten, Armin4, Author
Toni, Nicolas5, Author
Kherif, Ferath1, Author
Heuser, Isabella2, Author
Draganski, Bogdan6, 7, Author              
Affiliations:
1Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department Psychiatry, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department of Clinical Neurosciences, School of Medicine, University of Geneva, Switzerland, ou_persistent22              
4Department of Psychiatry, School of Medicine, University of Geneva, Switzerland, ou_persistent22              
5Centre for Psychiatric Neurosciences, Department of Psychiatry, School of Medicine, University of Geneva, Switzerland, ou_persistent22              
6University of Lausanne, Switzerland, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Depression; Neuroscience
 Abstract: Despite decades of successful treatment of therapy-resistant depression and major scientific advances in the field, our knowledge about electro-convulsive therapy's (ECT) mechanisms of action is still scarce. Building on strong empirical evidence for ECT-induced hippocampus anatomy changes, we sought to test the hypothesis that ECT has a differential impact along the hippocampus longitudinal axis. We acquired behavioural and brain anatomy magnetic resonance imaging (MRI) data in patients with depressive episode undergoing ECT (n = 9) or pharmacotherapy (n = 24) and healthy controls (n = 30) at two time points 3 months apart. Using whole-brain voxel-based statistical parametric mapping and topographic analysis focused on the hippocampus, we observed ECT-induced gradient of grey matter volume increase along the hippocampal longitudinal axis with predominant impact on its anterior portion. Clinical outcome measures showed strong correlations with both baseline volume and rate of ECT-induced change exclusively for the anterior, but not posterior hippocampus. We interpret our findings confined to the anterior hippocampus and amygdala as additional evidence of the regional specific impact of ECT that unfolds its beneficial effect on depression via the "limbic" system. Main limitations of the study are patients' polypharmacy, heterogeneity of psychiatric diagnosis, and long-time interval between scans.

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Language(s): eng - English
 Dates: 2021-02-122020-07-182021-03-022021-03-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41398-021-01310-0
PMID: 33782387
PMC: PMC8007583
 Degree: -

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Project name : -
Grant ID : 32003B_159780, CRSK-3_190185, 324730_192755, 173128
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : Horizon 2020
Grant ID : 871643
Funding program : -
Funding organization : European Union

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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
 Creator(s):
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 11 Sequence Number: 191 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188