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  3D interrelationship between osteocyte network and forming mineral during human bone remodeling

Ayoubi, M., Van Tol, A., Weinkamer, R., Roschger, P., Brugger, P. C., Berzlanovich, A., et al. (2021). 3D interrelationship between osteocyte network and forming mineral during human bone remodeling. Advanced Healthcare Materials, 10(12): 2100113. doi:10.1002/adhm.202100113.

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Ayoubi, Mahdi1, Author              
Van Tol, Alexander1, Author              
Weinkamer, Richard1, Author              
Roschger, Paul, Author
Brugger, Peter C., Author
Berzlanovich, Andrea, Author
Bertinetti, Luca2, Author              
Roschger, Andreas3, Author              
Fratzl, Peter4, Author              
Affiliations:
1Richard Weinkamer, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863295              
2Luca Bertinetti, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2379691              
3Wolfgang Wagermaier, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863296              
4Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

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Free keywords: biomineralization, bone remodeling, FIB–SEM tomography, iodine vapor staining, lacunocanalicular network (LCN), mineralization foci
 Abstract: During bone remodeling, osteoblasts are known to deposit unmineralized collagenous tissue (osteoid), which mineralizes after some time lag. Some of the osteoblasts differentiate into osteocytes, forming a cell network within the lacunocanalicular network (LCN) of bone. To get more insight into the potential role of osteocytes in the mineralization process of osteoid, sites of bone formation are three-dimensionally imaged in nine forming human osteons using focused ion beam-scanning electron microscopy (FIB-SEM). In agreement with previous observations, the mineral concentration is found to gradually increase from the central Haversian canal toward pre-existing mineralized bone. Most interestingly, a similar feature is discovered on a length scale more than 100-times smaller, whereby mineral concentration increases from the LCN, leaving around the canaliculi a zone virtually free of mineral, the size of which decreases with progressing mineralization. This suggests that the LCN controls mineral formation but not just by diffusion of mineralization precursors, which would lead to a continuous decrease of mineral concentration from the LCN. The observation is, however, compatible with the codiffusion and reaction of precursors and inhibitors from the LCN into the bone matrix.

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Language(s): eng - English
 Dates: 2021-05-082021
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/adhm.202100113
BibTex Citekey: https://doi.org/10.1002/adhm.202100113
PMID: 0611
Other: M:\BM-Publications\2021\AyoubiAdvHealthcareMater_Three-dimensional
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Title: Advanced Healthcare Materials
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 10 (12) Sequence Number: 2100113 Start / End Page: - Identifier: ISSN: 2192-2640