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  Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard

Herz, K., Mueller, S., Perlman, O., Zaitsev, M., Knutsson, L., Sun, P., et al. (2021). Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard. Magnetic Resonance in Medicine, 86(4), 1845-1858. doi:10.1002/mrm.28825.

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Herz, K1, 2, Author              
Mueller, S1, 2, Author              
Perlman, O, Author
Zaitsev , M, Author
Knutsson, L, Author
Sun, PZ, Author
Zhou, J, Author
van Zijl, P, Author
Heinecke, K, Author
Schuenke, P, Author
Farrar, CT, Author
Schmidt, M, Author
Dörfler, A, Author
Scheffler, K1, 2, Author              
Zaiss, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Purpose: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols. Methods: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module. Results: The exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer-weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility. Conclusion: With Pulseq-CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.

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 Dates: 2021-052021-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.28825
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 86 (4) Sequence Number: - Start / End Page: 1845 - 1858 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149