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  Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard

Herz, K., Mueller, S., Perlman, O., Zaitsev, M., Knutsson, L., Sun, P., et al. (2021). Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard. Magnetic Resonance in Medicine, 86(4), 1845-1858. doi:10.1002/mrm.28825.

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Herz, K1, 2, Autor           
Mueller, S1, 2, Autor           
Perlman, O, Autor
Zaitsev , M, Autor
Knutsson, L, Autor
Sun, PZ, Autor
Zhou, J, Autor
van Zijl, P, Autor
Heinecke, K, Autor
Schuenke, P, Autor
Farrar, CT, Autor
Schmidt, M, Autor
Dörfler, A, Autor
Scheffler, K1, 2, Autor           
Zaiss, M1, 2, Autor           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Zusammenfassung: Purpose: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.

Methods: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module.

Results: The exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer-weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility.

Conclusion: With Pulseq-CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.

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 Datum: 2021-052021-10
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1002/mrm.28825
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Titel: Magnetic Resonance in Medicine
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 86 (4) Artikelnummer: - Start- / Endseite: 1845 - 1858 Identifikator: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149