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  Predictors of post-stroke aphasia recovery: A systematic review-informed individual participant data meta-analysis

RELEASE Collaboration, & Stahl, B. (2021). Predictors of post-stroke aphasia recovery: A systematic review-informed individual participant data meta-analysis. Stroke, 52(5), 1778-1787. doi:10.1161/strokeaha.120.031162.

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RELEASE_Collaboration_Stroke_2021.pdf (Publisher version), 2MB
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RELEASE Collaboration, Author              
Stahl, Benjamin1, Author              
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1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Aphasia; Demography; Comprehension; Survivor; Language
 Abstract: Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. Conclusions: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.

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Language(s): eng - English
 Dates: 2020-10-312020-06-232020-11-252021-03-152021-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1161/strokeaha.120.031162
Other: epub 2021
PMID: 33719515
PMC: PMC8078126
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Title: Stroke
Source Genre: Journal
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Publ. Info: Philadelphia, PA : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 52 (5) Sequence Number: - Start / End Page: 1778 - 1787 Identifier: ISSN: 0039-2499
CoNE: https://pure.mpg.de/cone/journals/resource/954925447729