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  Towards precision medicine in psychosis: Benefits and challenges of multimodal multicenter studies—PSYSCAN: Translating neuroimaging findings from research into clinical practice

Tognin, S., van Hell, H., Merritt, K., Rossum, I., Bossong, M., Kempton, M., et al. (2020). Towards precision medicine in psychosis: Benefits and challenges of multimodal multicenter studies—PSYSCAN: Translating neuroimaging findings from research into clinical practice. Schizophrenia Bulletin, 46(2), 432-441. doi:10.1093/schbul/sbz067.

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Tognin, S. 1, 2, Author
van Hell, H.3, Author
Merritt, K.1, Author
Rossum, I.3, Author
Bossong, M.3, Author
Kempton, M.1, Author
Modinos, G.1, Author
Fusar-Poli, P.1, 4, 5, Author
Mechelli, A.1, Author
Dazzan, P.1, Author
Maat, A.3, Author
de Haan, L.6, Author
Crespo-Facorro, B.7, 8, 9, Author
Glenthøj, B.10, 11, Author
Lawrie, S.12, Author
McDonald, C.13, Author
Gruber, O.14, Author
van Amelsvoort, T.15, Author
Arango, C.16, Author
Kircher, T.17, Author
Nelson, B.18, 19, AuthorGalderisi, S.20, AuthorBressan, R.21, AuthorKwon, J.22, AuthorWeiser, M.23, 24, AuthorMizrahi, R.25, 26, 27, AuthorSachs, G.28, AuthorMaatz, A.29, AuthorKahn, R.3, 30, AuthorMcGuire, P.1, 2, 5, AuthorPSYSCAN Consortium, Author              Berger, Philipp31, Author            more..
1Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, ou_persistent22              
2Outreach and Support in South London (OASIS), South London and Maudsley NHS Foundation Trust, ou_persistent22              
3Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, ou_persistent22              
4Department of Brain and Behavioral Sciences, University of Pavia, ou_persistent22              
5National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, ou_persistent22              
6Department Early Psychosis, Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, ou_persistent22              
7CIBERSAM, Department of Psychiatry, University Hospital Virgen del Rocío, ou_persistent22              
8IDIVAL, Marqués de Valdecilla University Hospital, Santander, ou_persistent22              
9School of Medicine, University of Cantabria, Santander, ou_persistent22              
10Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, ou_persistent22              
11Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, ou_persistent22              
12Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, ou_persistent22              
13Centre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, ou_persistent22              
14Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, ou_persistent22              
15Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, ou_persistent22              
16Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, School of Medicine, Universidad Complutense, ou_persistent22              
17Department of Psychiatry, University of Marburg, Marburg, ou_persistent22              
18Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, ou_persistent22              
19Centre for Youth Mental Health, The University of Melbourne, Melbourne, ou_persistent22              
20Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, ou_persistent22              
21Interdisciplinary Lab for Clinical Neurosciences (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, ou_persistent22              
22Department of Psychiatry, Seoul National University College of Medicine, Seoul, ou_persistent22              
23Department of Psychiatry, Sheba Medical Center, Tel Hashomer, ou_persistent22              
24Sackler School of Medicine, Tel Aviv University, ou_persistent22              
25Institute of Medical Science, University of Toronto, ou_persistent22              
26Centre for Addiction and Mental Health, Toronto, ou_persistent22              
27Department of Psychiatry, University of Toronto, Toronto, ou_persistent22              
28Department of Psychiatry and Psychotherapy, Medical University of Vienna, ou_persistent22              
29Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, ou_persistent22              
30Department of Psychiatry, Icahn School of Medicine at Mount Sinai, ou_persistent22              
31External Organizations, ou_persistent22              


Free keywords: MRI; PSYSCAN; clinical high risk of psychosis; first episode of psychosis; machine learning; neuroimaging; prediction; psychosis
 Abstract: In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical outcome. Despite advancements in the field, neuroimaging has yet to deliver. This is in part explained by the use of univariate analytical techniques, small samples and lack of statistical power, lack of external validation of potential biomarkers, and lack of integration of nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN is an international, longitudinal, multicenter study on the early stages of psychosis which uses machine learning techniques to analyze imaging, clinical, cognitive, and biological data with the aim of facilitating the prediction of psychosis onset and outcome. In this article, we provide an overview of the PSYSCAN protocol and we discuss benefits and methodological challenges of large multicenter studies that employ neuroimaging measures.


Language(s): eng - English
 Dates: 2019-08-192020-03-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/schbul/sbz067
PMID: 31424555
PMC: PMC7043057
 Degree: -



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Project name : -
Grant ID : 603196
Funding program : -
Funding organization : European Union

Source 1

Title: Schizophrenia Bulletin
  Other : Schizophr. Bull.
Source Genre: Journal
Publ. Info: -
Pages: - Volume / Issue: 46 (2) Sequence Number: - Start / End Page: 432 - 441 Identifier: ISSN: 0586-7614
CoNE: https://pure.mpg.de/cone/journals/resource/954925532975