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  Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain

Goeksu, C., Scheffler, K., Gregersen, F., Eroğlu, H., Heule, R., Siebner, H., et al. (2021). Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain. Poster presented at 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

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Goeksu, C1, 2, Author              
Scheffler, K1, 2, Author              
Gregersen, F, Author
Eroğlu, HH, Author
Heule, R1, 2, Author              
Siebner, HR, Author
Hanson, LG, Author
Thielscher, A, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Effective use of transcranial electrical stimulation (TES) in clinical and neuroscience applications requires the exact knowledge of TES currents. MRCDI uses MRI to measure the TES-induced magnetic fields for estimating the underlying current flow distributions. Their accuracy highly depends on the sensitivity and spatial resolution of the MR measurements. Here, we propose an advanced gradient-echo-based MRCDI method utilizing an optimized spoiling, acquisition-weighting, and navigators to achieve a noise sensitivity of 84pT at 2×2×3mm3 resolution for a total scan time of less than five minutes. We test the method's performance by phantom and human in-vivo experiments for two TES injection profiles.

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 Dates: 2021-05
 Publication Status: Published online
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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
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Start-/End Date: 2021-05-15 - 2021-05-20

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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: 3788 Start / End Page: - Identifier: -