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  Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn

Guo, S., Huang, S., Jiang, X., Hu, H., Han, D., Moreno, C. S., et al. (2021). Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn. BMC Genomics, 22: 286. doi:10.1186/s12864-021-07542-0.

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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 Creators:
Guo, Song, Author
Huang, Shuyun, Author
Jiang, Xi, Author
Hu, Haiyang, Author
Han, Dingding, Author
Moreno, Carlos S., Author
Fairbrother, Genevieve L., Author
hughes, David A., Author
Stoneking, Mark1, Author                 
Khaitovich, Philipp, Author
Affiliations:
1Human Population History, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2074313              

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 Abstract: Analysis of lymphocyte cell lines revealed substantial differences in the expression of mRNA and microRNA (miRNA) among human populations. The extent of such population-associated differences in actual human tissues remains largely unexplored. The placenta is one of the few solid human tissues that can be collected in substantial numbers in a controlled manner, enabling quantitative analysis of transient biomolecules such as RNA transcripts. Here, we analyzed microRNA (miRNA) expression in human placental samples derived from 36 individuals representing four genetically distinct human populations: African Americans, European Americans, South Asians, and East Asians. All samples were collected at the same hospital following a unified protocol, thus minimizing potential biases that might influence the results.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1186/s12864-021-07542-0
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Title: BMC Genomics
Source Genre: Journal
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Pages: - Volume / Issue: 22 Sequence Number: 286 Start / End Page: - Identifier: ISBN: 1471-2164