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  Lack of interaction of vasopressin with its antisense peptides: a functional and immunological study

Jurzak, M., Pávó, I., & Fahrenholz, F. (1993). Lack of interaction of vasopressin with its antisense peptides: a functional and immunological study. Journal of receptor research, 13(5), 881-902. doi:10.3109/10799899309073699.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-A54E-7 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-A54F-6
Genre: Zeitschriftenartikel

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 Urheber:
Jurzak, Mirek1, Autor           
Pávó, Imre1, Autor           
Fahrenholz, Falk1, Autor           
Affiliations:
1Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_3273414              

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Schlagwörter: -
 Zusammenfassung: The peptide encoded in the 5' to 3' direction by rat vasopressin complementary RNA, rat PVA (H-Ser-Ser-Trp-Ala-Val-Leu-Glu-Val-Ala- OH) and the corresponding bovine PVA (H-Ala-Pro-Trp-Ala-Val-Leu-Glu-Val-Ala-OH) were investigated with respect to their interaction with [8-arginine] vasopressin (AVP) and V2 vasopressin receptor binding and function. Rat or bovine PVA did neither affect the binding of the hormone to the V2 receptor of bovine kidney membranes and LLC-PK1 pig kidney cells nor influence the AVP-induced cAMP-production in LLC-PK1 cells. Rat PVA was further investigated by the use of vasopressin-specific polyclonal and monoclonal antibodies with different affinity and epitope specificity. Consistent with receptor binding studies no inhibition of [3H]AVP-binding in fluid- or solid-phase antibody binding tests after preincubation with PVA was found. Direct interaction of rat PVA and [3H]AVP measured on solid surface was not observed in contrast to specific binding of the hormone with NP II and antibodies. In our study no evidence for an interaction of AVP and its antisense peptides was found.

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Sprache(n): eng - English
 Datum: 2008-09-261993
 Publikationsstatus: Erschienen
 Seiten: 23
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.3109/10799899309073699
PMID: 8385219
 Art des Abschluß: -

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Titel: Journal of receptor research
  Kurztitel : J Recept Res
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, N.Y. : Marcel Dekker
Seiten: - Band / Heft: 13 (5) Artikelnummer: - Start- / Endseite: 881 - 902 Identifikator: ISSN: 0197-5110