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  Two mechanisms drive pronuclear migration in mouse zygotes

Scheffler, K., Uraji, J., Jentoft, I., Cavazza, T., Mönnich, E., Mogessie, B., et al. (2021). Two mechanisms drive pronuclear migration in mouse zygotes. Nature Communications, 12: 841. doi:10.1038/s41467-021-21020-x.

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 Creators:
Scheffler, K.1, Author              
Uraji, J.1, Author              
Jentoft, Ida, Author
Cavazza, T.1, Author              
Mönnich, Eike, Author
Mogessie, B.1, Author              
Schuh, M.1, Author              
Affiliations:
1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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Free keywords: Cytoskeleton; Embryogenesis
 Abstract: A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei near the surface of the fertilized egg. The mechanisms that then move the pronuclei inwards for their unification are only poorly understood in mammals. Here, we report two mechanisms that act in concert to unite the parental genomes in fertilized mouse eggs. The male pronucleus assembles within the fertilization cone and is rapidly moved inwards by the flattening cone. Rab11a recruits the actin nucleation factors Spire and Formin-2 into the fertilization cone, where they locally nucleate actin and further accelerate the pronucleus inwards. In parallel, a dynamic network of microtubules assembles that slowly moves the male and female pronuclei towards the cell centre in a dynein-dependent manner. Both mechanisms are partially redundant and act in concert to unite the parental pronuclei in the zygote’s centre.

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Language(s): eng - English
 Dates: 2021-02-05
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-21020-x
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Title: Nature Communications
Source Genre: Journal
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Pages: 18 Volume / Issue: 12 Sequence Number: 841 Start / End Page: - Identifier: -