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  Phase separation during germline development

So, C., Cheng, S., & Schuh, M. (2021). Phase separation during germline development. Trends in Cell Biology, 31(4), 254-268. doi:10.1016/j.tcb.2020.12.004.

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So, C.1, Author           
Cheng, S.1, Author           
Schuh, M.1, Author           
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1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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Free keywords: phase separation; biomolecular condensates; germline development; germ cells; meiosis; oocytes
 Abstract: Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work has revealed crucial functions for phase separation during germline development. Phase separation controls the assembly and segregation of germ granules that determine which embryonic cells become germ cells. Phase separation promotes the formation of the Balbiani body, a structure that stores organelles and RNAs during the prolonged prophase arrest of oocytes. Phase separation also facilitates meiotic recombination that prepares homologous chromosomes for segregation, and drives the formation of a liquid-like spindle domain that promotes spindle assembly in mammalian oocytes. We review how phase separation drives these essential steps during germline development.

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Language(s): eng - English
 Dates: 2021-01-142021-04
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.tcb.2020.12.004
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Title: Trends in Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 31 (4) Sequence Number: - Start / End Page: 254 - 268 Identifier: -