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  Free flow micropuncture studies of glucose transport in the rat nephron

Frohnert, P. P., Höhmann, B., Zwiebel, R., & Baumann, K. (1970). Free flow micropuncture studies of glucose transport in the rat nephron. Pflügers Archiv: European Journal of Physiology, 315(1), 66-85. doi:10.1007/BF00587238.

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 Creators:
Frohnert, Peter P.1, Author           
Höhmann, Bernhard1, Author           
Zwiebel, Ralf1, Author           
Baumann, Karl1, Author           
Affiliations:
1Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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Free keywords: Free Flow Micropuncture; D-Glucose; Transtubular Transport; Proximal and Distal Tubule; Physiologic Glucosuria
 Abstract: Tubular free flow micropuncture studies were done in normoglycemic rats to evaluated-glucose handling along the nephron.
1. A rapid removal of filtered glucose occured over the first three millimeters of the proximal tubule.
2. The intratubular glucose concentration remained constant at 0.25±0.20 mmol/l (SD) over the second half of the accessible proximal tubule. This value is similar to one predicted on the basis of kinetic data obtained previously under conditions of zero volume flux.
3. More than 98 per cent of the filtered glucose was reabsorbed by the proximal tubule.
4. No further net flux was detectable between the proximal segment and the end of the distal tubule accessible to micropuncture.
5. The collecting duct reduced glucose excretion to less than 0.1 per cent of the filtered load. The final rate of glucose excretion was independent of the rate of urine flow.

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Language(s): eng - English
 Dates: 1969-11-101970-03-01
 Publication Status: Issued
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00587238
 Degree: -

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Title: Pflügers Archiv: European Journal of Physiology
  Other : Pflügers Arch. Europ. J. Physiol.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 315 (1) Sequence Number: - Start / End Page: 66 - 85 Identifier: ISSN: 0031-6768
CoNE: https://pure.mpg.de/cone/journals/resource/954925432380