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  Influence of luminal diameter and flow velocity on the isotonic fluid absorption and 36Cl permeability of the proximal convolution of the rat kidney

Radtke, H. W., Rumrich, G., Klöss, S., & Ullrich, K. J. (1971). Influence of luminal diameter and flow velocity on the isotonic fluid absorption and 36Cl permeability of the proximal convolution of the rat kidney. Pflügers Archiv: European Journal of Physiology, 324(4), 288-296. doi:10.1007/BF00592457.

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 Creators:
Radtke, Heinz W.1, Author           
Rumrich, Gerhard1, Author           
Klöss, Sonja1, Author           
Ullrich, Karl Julius1, Author           
Affiliations:
1Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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Free keywords: Renal Microperfusion; Isotonic Reabsorption; Tracer Permeability; Glomerulo Tubular Balance
 Abstract: In the first experimental series proximal convolutions of the rat kidney were perfused with a modified Ringer solution and the isotonic fluid absorption was measured. In a second series the tubule was perfused with equilibrium solution which contained 36Cl and the chloride permeability was determined. By the recollection method each individual tubule was perfused twice either at constant luminal diameter but different perfusion rates (10:30 or 6:16 nl/min) or at constant perfusion rates but different luminal diameters (20:30 μ). The perfusate was recollected at two different sites which were at least 500 μ distant from the infusion site.

The isotonic fluid absorption as well as the 36Cl permeability was unchanged when the tubule was distended from 20–30 μ. Both, however, increased about 20% when the perfusion rate was increased 3-fold.

The data led to the following conclusions: 1. It is unlikely that there is a flow reactor type dependence of proximal tubular transport on flow rate. 2. The tubular distension cannot be responsible for the glomerulo-tubular balance. 3. It is more advantageous to relate permeability data of the rat nephron to tubular length. 4. In microperfusion experiments non steady sampling does not affect transepithelial fluxes per unit tubular length, provided that the pump delivery is constant.

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Language(s): eng - English
 Dates: 1970-11-171971-12-01
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00592457
PMID: 5103162
 Degree: -

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Title: Pflügers Archiv: European Journal of Physiology
  Other : Pflügers Arch. Europ. J. Physiol.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 324 (4) Sequence Number: - Start / End Page: 288 - 296 Identifier: ISSN: 0031-6768
CoNE: https://pure.mpg.de/cone/journals/resource/954925432380