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  Purification and analysis of partially alkylated cyclodextrins by liquid and gas chromatography

Deege, A., Husmann, H., Hübinger, E., Kobor, F., & Schomburg, G. (1993). Purification and analysis of partially alkylated cyclodextrins by liquid and gas chromatography. Journal of High Resolution Chromatography, 16(10), 587-593. doi:10.1002/jhrc.1240161004.

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Genre: Journal Article

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 Creators:
Deege, Alfred1, Author              
Husmann, Heribert1, Author
Hübinger, Eduard1, Author
Kobor, Frank1, Author
Schomburg, Gerhard1, Author              
Affiliations:
1Service Department Schomburg (GC), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445628              

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Free keywords: Partially alkylated cyclodextrins; High temperature Capillary GC; Trimethylsilylation; Preparative LC; FAB mass spectrometry
 Abstract: Complex mixtures of partially alkylated cyclodextrins can be analyzed by both HPLC and high temperature capillary GC. Because of the limited efficiency of LC, suitable analytical and preparative separations can be achieved only with systems of carefully optimized selectivity. Using LC it has been possible to isolate and purify single cyclodextrin species from very complex mixtures of components which contain unreacted hydroxyl groups in addition to the alkoxy groups. Analysis of the reaction mixtures and of fractions taken from LC separations can be performed with advantage by high resolution capillary GC at high temperatures between 300 and 400 °C. The thermal stability of partially alkylated cyclodextrins in high temperature GC is considerably increased by trimethylsilylation of the free hydroxyl groups. Fast atom bombardment mass spectrometry and proton NMR were used to identify species isolated from the preparative LC separations.

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Language(s): eng - English
 Dates: 1993-10-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/jhrc.1240161004
 Degree: -

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Title: Journal of High Resolution Chromatography
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Heidelberg : A. Huethig
Pages: - Volume / Issue: 16 (10) Sequence Number: - Start / End Page: 587 - 593 Identifier: ISSN: 0935-6304
CoNE: https://pure.mpg.de/cone/journals/resource/110994954485022