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  Quantification of Human Brain Metabolites using Two-Dimensional J-Resolved Metabolite-Cycled semiLASER at 9.4 T

Murali-Manohar, S., Borbath, T., Wright, A., & Henning, A. (2021). Quantification of Human Brain Metabolites using Two-Dimensional J-Resolved Metabolite-Cycled semiLASER at 9.4 T. In 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

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Murali-Manohar, S1, 2, Author              
Borbath, T1, 2, Author              
Wright, AM1, 2, Author              
Henning, A1, 2, Author              
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1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Crowded proton spectra with severely overlapped J-coupled resonances pose a challenge in the reliable quantification of metabolites in the human brain. Several advanced techniques such as editing methods, multi-dimensional spectroscopy methods, sophisticated processing or quantification pipelines were proposed in the past. In this work, we present a two-dimensional metabolite-cycled semiLASER technique at 9.4 T with maximum echo sampling scheme. This method helps well resolve the J-coupled peaks and clearly distinguish them. 2D spectral fitting is performed using ProFit2.0 and the metabolites are quantified using internal water referencing after correcting the fitted concentration for tissue content and relaxation effects.

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 Dates: 2021-05
 Publication Status: Published online
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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
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Start-/End Date: 2021-05-15 - 2021-05-20

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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0284 Start / End Page: - Identifier: -