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  Simultaneous Detection of Metabolite Concentration Changes, Water BOLD Signal and pH Changes during Visual Stimulation in the Human Brain at 9.4T

Dorst, J., Borbath, T., & Henning, A. (2021). Simultaneous Detection of Metabolite Concentration Changes, Water BOLD Signal and pH Changes during Visual Stimulation in the Human Brain at 9.4T. In 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

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Dorst, J1, 2, Author              
Borbath, T1, 2, Author              
Henning, A1, 2, Author              
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1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Previous studies investigated relationships between the BOLD signal and metabolite concentration changes during visual stimulation by sequential or interleaved fMRI/fMRS measurements. The purpose of this study was to simultaneously investigate the dynamics of BOLD signal and metabolite levels in the activated human brain at 9.4T using the metabolite-cycling (MC) technique. A correlation between the MC water dynamics and concentration increases of lactate and glutamate during activation could be verified. Besides, it could be shown that the high spectral quality of fMRS at 9.4T facilitates separate fitting of creatine and phosphocreatine thereby enabling the calculation of pH dynamics during visual stimulation.

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 Dates: 2021-05
 Publication Status: Published online
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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
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Start-/End Date: 2021-05-15 - 2021-05-20

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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0339 Start / End Page: - Identifier: -