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  The distribution of membrane bound enzymes in the acini and ducts of the cat pancreas

Wizemann, V., Christian, A.-L., Wiechmann, J., & Schulz, I. (1974). The distribution of membrane bound enzymes in the acini and ducts of the cat pancreas. Pflügers Archiv: European Journal of Physiology, 347(1), 39-47. doi:10.1007/BF00587053.

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 Creators:
Wizemann, Volker1, Author           
Christian, Anna-Luise1, Author           
Wiechmann, Jutta1, Author           
Schulz, Irene1, Author           
Affiliations:
1Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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Free keywords: Pancreas; Acini; Ducts; Membrane Enzymes
 Abstract: Enzymes activities of the Na+K+-and the HCO3-ATPases, alkaline phosphatase, amino peptidase and 5′ nucleotidase have been measured in 4 different preparations from the cat pancreas a) in the ducts including all sizes b) in ducts of three different diameters c) in that tissue, which had been dissected off from the ducts, called “acini”, and d) in the whole homogenate of the pancreas. The distribution of the measured enzymes shows, that the Na+K+-activity is highest in the acinar structures (mean value 0.532 μM/mg Protein x h), while the ducts show nearly no Na+K+-ATPase activity. The HCO3-ATPase, the alkaline phosphatase and the 5′ nucleotidase are in the ducts between 2.4 and 3.6 times higher than in the whole organ whereas the amino peptidase does not appear to have a selective distribution. As the HCO3-ATPase activity distribution pattern is identical with that of the secretory capacity of HCO3 as evidenced by earlier micropuncture studies, the data suggest that the HCO3-ATPase is the main enzyme involved in the secretion of the bicarbonate buffer. Concerning the Na+K+-ATPase activity in the acinar structures we cannot contribute to its function in the enzyme secreting process.

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Language(s): eng - English
 Dates: 1973-09-281974-02-18
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00587053
PMID: 4276254
 Degree: -

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Title: Pflügers Archiv: European Journal of Physiology
  Other : Pflügers Arch. Europ. J. Physiol.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 347 (1) Sequence Number: - Start / End Page: 39 - 47 Identifier: ISSN: 0031-6768
CoNE: https://pure.mpg.de/cone/journals/resource/954925432380