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Enantiomeric olefins; Platinum complexes; Ligand exchange; Preparative gas chromatography; Preparative column-liquid chromatography; Column switching
Abstract:
Diastereomer formation by the reaction of chiral olefins with optically active platinum complexes followed by LC separation of the diastereomers, and on-line or off-line release of the olefins from the complexes by ligand exchange yield optically pure enantiomers.
The 100% dextrostetatory enantiomer of exo-2-vinylbicyclo[2.2.1]heptane (vinylnorbornane) could be isolated by an off-line method and was used for polarimetric measurements before and after preparative scale gas chromatographic clean-up.
The initial valuable platinum complex could be easily recovered without loss.
