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Abstract:
In natural metabolic networks, more than 2000 different biochemical
reactions are operated and spatially and temporally co-ordinated in a
reaction volume of <1 mu m(3). A similar level of control and precision
has not been achieved in chemical synthesis, so far. Recently, synthetic
biology succeeded in reconstructing complex synthetic in vitro metabolic
networks (SIVMNs) from individual proteins in a defined fashion
bottom-up. In this review, we will highlight some examples of SIVMNs and
discuss how the further advancement of SIVMNs will require the
structural organization of these networks and their reactions to (i)
minimize deleterious side reactions, (ii) efficiently energize these
networks from renewable energies, and (iii) achieve high productivity.
The structural organization of synthetic metabolic networks will be a
key step to create novel catalytic systems of the future and advance
ongoing efforts of creating cell-like systems and artificial cells.
