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  Anticipating the impact of COVID19 and comorbidities on the South African healthcare system by agent-based simulations

Schlüter, J. C., Sörensen, L., Bossert, A., Kersting, M., Staab, W., & Wacker, B. (2021). Anticipating the impact of COVID19 and comorbidities on the South African healthcare system by agent-based simulations. Scientific Reports, 11: 7901. doi:10.1038/s41598-021-86580-w.

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 Creators:
Schlüter, Jan Christian1, Author           
Sörensen, Leif1, Author           
Bossert, Andreas1, Author           
Kersting, Moritz1, Author           
Staab, Wieland, Author
Wacker, Benjamin1, Author           
Affiliations:
1Group Next generation mobility, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2466705              

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 Abstract: Tuberculosis (TB) is the 10th leading cause of death worldwide, and since 2007 it has been the main cause of death from a single infectious agent, ranking above HIV/AIDS. The current COVID-19 is a pandemic which caused many deaths around the world. The danger is not only a coinfection as observed for TB and HIV for a long time, but that both TB and SARS-CoV-2 affect the respiratory organs and thus potentiate their effect or accelerate the critical course. A key public health priority during the emergence of a novel pathogen is the estimation of the clinical need to assure adequate medical treatment. This requires a correct adjustment to the critical case detection rate and the prediction of possible scenarios based on known patterns. The African continent faces constraining preconditions in regard to healthcare capacities and social welfare which may hinder required countermeasures. However, given the high TB prevalence rates, COVID-19 may show a particular severe course in respective African countries, e.g. South Africa. Using WHO’s TB and public infrastructure data, we conservatively estimate that the symptomatic critical case rate, which affects the healthcare system, is between 8 and 12% due to the interaction of COVID-19 and TB, for a TB population of 0.52% in South Africa. This TB prevalence leads to a significant increase in the peak load of critical cases of COVID-19 patients and potentially exceeds current healthcare capacities.

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Language(s): eng - English
 Dates: 2021-04-122021
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-021-86580-w
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Title: Scientific Reports
Source Genre: Journal
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Pages: 9 Volume / Issue: 11 Sequence Number: 7901 Start / End Page: - Identifier: ISSN: 2045-2322